2jqq

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{{Seed}}
 
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[[Image:2jqq.png|left|200px]]
 
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==Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)==
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The line below this paragraph, containing "STRUCTURE_2jqq", creates the "Structure Box" on the page.
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<StructureSection load='2jqq' size='340' side='right'caption='[[2jqq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JQQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqq OCA], [https://pdbe.org/2jqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jqq RCSB], [https://www.ebi.ac.uk/pdbsum/2jqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jqq ProSAT]</span></td></tr>
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{{STRUCTURE_2jqq| PDB=2jqq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COG2_YEAST COG2_YEAST] Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.<ref>PMID:9606204</ref> <ref>PMID:12006647</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The conserved oligomeric Golgi (COG) complex is strongly implicated in retrograde vesicular trafficking within the Golgi apparatus. Although its mechanism of action is poorly understood, it has been proposed to function by mediating the initial physical contact between transport vesicles and their membrane targets. An analogous role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex essential for trafficking to the plasma membrane. Here we report the solution structure of a large portion of yeast Cog2p, one of eight subunits composing the COG complex. The structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. This finding provides the first structural evidence that COG, like the exocyst and potentially other tethering complexes, is constructed from helical bundles. These structures may represent platforms for interaction with other trafficking proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs.
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===Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)===
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Structural analysis of conserved oligomeric Golgi complex subunit 2.,Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J, Hughson FM J Biol Chem. 2007 Aug 10;282(32):23418-26. Epub 2007 Jun 12. PMID:17565980<ref>PMID:17565980</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17565980}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jqq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17565980 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17565980}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQQ OCA].
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==Reference==
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Structural analysis of conserved oligomeric Golgi complex subunit 2., Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J, Hughson FM, J Biol Chem. 2007 Aug 10;282(32):23418-26. Epub 2007 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17565980 17565980]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Cavanaugh LF]]
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[[Category: Cavanaugh, L F.]]
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[[Category: Chen X]]
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[[Category: Chen, X.]]
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[[Category: Hughson FM]]
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[[Category: Hughson, F M.]]
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[[Category: Pelczer I]]
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[[Category: Pelczer, I.]]
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[[Category: Rizo J]]
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[[Category: Rizo, J.]]
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[[Category: Helical bundle]]
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[[Category: Protein]]
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[[Category: Tethering]]
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[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:19:14 2008''
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Current revision

Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p)

PDB ID 2jqq

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