2bzy

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{{Seed}}
 
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[[Image:2bzy.png|left|200px]]
 
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==Homodimer of CrkL-SH3C domain==
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The line below this paragraph, containing "STRUCTURE_2bzy", creates the "Structure Box" on the page.
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<StructureSection load='2bzy' size='340' side='right'caption='[[2bzy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bzy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzy OCA], [https://pdbe.org/2bzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzy RCSB], [https://www.ebi.ac.uk/pdbsum/2bzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzy ProSAT]</span></td></tr>
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{{STRUCTURE_2bzy| PDB=2bzy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRKL_HUMAN CRKL_HUMAN] May mediate the transduction of intracellular signals.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bzy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CRKL plays essential roles in cell signaling. It consists of an N-terminal SH2 domain followed by two SH3 domains. SH2 and SH3N bind to signaling proteins, but the function of the SH3C domain has remained largely enigmatic. We show here that the SH3C of CRKL forms homodimers in protein crystals and in solution. Evidence for dimer formation of full-length CRKL is also presented. In the SH3C dimer, a nuclear export signal (NES) is mostly buried under the domain surface. The same is true for a monomeric SH3C obtained under different crystallization conditions. Interestingly, partial SH3 unfolding, such as occurs upon dimer/monomer transition, produces a fully-accessible NES through translocation of a single beta strand. Our results document the existence of an SH3 domain dimer formed through exchange of the first SH3 domain beta strand and suggest that partial unfolding of the SH3C is important for the relay of information in vivo.
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===HOMODIMER OF CRKL-SH3C DOMAIN===
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The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.,Harkiolaki M, Gilbert RJ, Jones EY, Feller SM Structure. 2006 Dec;14(12):1741-53. PMID:17161365<ref>PMID:17161365</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17161365}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bzy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17161365 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17161365}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BZY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZY OCA].
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==Reference==
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The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal., Harkiolaki M, Gilbert RJ, Jones EY, Feller SM, Structure. 2006 Dec;14(12):1741-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17161365 17161365]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Feller, S M.]]
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[[Category: Feller SM]]
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[[Category: Gilbert, R J.]]
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[[Category: Gilbert RJ]]
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[[Category: Harkiolaki, M.]]
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[[Category: Harkiolaki M]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Crk-like]]
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[[Category: Crkl]]
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[[Category: Dimer]]
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[[Category: Nuclear export]]
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[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:27:20 2008''
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Current revision

Homodimer of CrkL-SH3C domain

PDB ID 2bzy

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