3bej

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{{Seed}}
 
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[[Image:3bej.png|left|200px]]
 
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==Structure of human FXR in complex with MFA-1 and co-activator peptide==
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The line below this paragraph, containing "STRUCTURE_3bej", creates the "Structure Box" on the page.
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<StructureSection load='3bej' size='340' side='right'caption='[[3bej]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bej]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MUF:(8ALPHA,10ALPHA,13ALPHA,17BETA)-17-[(4-HYDROXYPHENYL)CARBONYL]ANDROSTA-3,5-DIENE-3-CARBOXYLIC+ACID'>MUF</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
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{{STRUCTURE_3bej| PDB=3bej | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bej OCA], [https://pdbe.org/3bej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bej RCSB], [https://www.ebi.ac.uk/pdbsum/3bej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bej ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bej_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bej ConSurf].
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<div style="clear:both"></div>
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===Structure of human FXR in complex with MFA-1 and co-activator peptide===
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18391212}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18391212 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_18391212}}
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==About this Structure==
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3BEJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA].
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==Reference==
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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation., Soisson SM, Parthasarathy G, Adams AD, Sahoo S, Sitlani A, Sparrow C, Cui J, Becker JW, Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5337-42. Epub 2008 Apr 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18391212 18391212]
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[[Category: Histone acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Becker, J W.]]
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[[Category: Becker JW]]
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[[Category: Parthasarathy, G]]
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[[Category: Parthasarathy G]]
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[[Category: Soisson, S M.]]
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[[Category: Soisson SM]]
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[[Category: Activator]]
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[[Category: Acyltransferase]]
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[[Category: Alternative splicing]]
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[[Category: Bar]]
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[[Category: Bile acid receptor]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Dna-binding]]
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[[Category: Fxr]]
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[[Category: Metal-binding]]
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[[Category: Nhr]]
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[[Category: Nr1h4]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Transcription/transferase complex]]
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[[Category: Transferase]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:30:11 2008''
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Current revision

Structure of human FXR in complex with MFA-1 and co-activator peptide

PDB ID 3bej

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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