1yvf

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{{Seed}}
 
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[[Image:1yvf.png|left|200px]]
 
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==Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145==
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The line below this paragraph, containing "STRUCTURE_1yvf", creates the "Structure Box" on the page.
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<StructureSection load='1yvf' size='340' side='right'caption='[[1yvf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH7:(2Z)-2-(BENZOYLAMINO)-3-[4-(2-BROMOPHENOXY)PHENYL]-2-PROPENOIC+ACID'>PH7</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1yvf| PDB=1yvf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvf OCA], [https://pdbe.org/1yvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvf RCSB], [https://www.ebi.ac.uk/pdbsum/1yvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvf ProSAT]</span></td></tr>
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</table>
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===Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145===
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== Function ==
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[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15863301}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15863301 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvf_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15863301}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvf ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15863301 15863301]
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</StructureSection>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Hepacivirus C]]
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[[Category: Anstadt, R A.]]
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[[Category: Large Structures]]
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[[Category: Finzel, B C.]]
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[[Category: Anstadt RA]]
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[[Category: Greene, M L.]]
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[[Category: Finzel BC]]
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[[Category: Gross, R J.]]
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[[Category: Greene ML]]
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[[Category: Harris, M S.]]
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[[Category: Gross RJ]]
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[[Category: Kilkuskie, R E.]]
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[[Category: Harris MS]]
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[[Category: Kopta, L A.]]
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[[Category: Kilkuskie RE]]
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[[Category: Mitchell, M A.]]
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[[Category: Kopta LA]]
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[[Category: Nugent, R A.]]
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[[Category: Mitchell MA]]
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[[Category: Pfefferkorn, J A.]]
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[[Category: Nugent RA]]
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[[Category: Schwende, F J.]]
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[[Category: Pfefferkorn JA]]
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[[Category: Shelly, J A.]]
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[[Category: Schwende FJ]]
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[[Category: Wells, P A.]]
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[[Category: Shelly JA]]
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[[Category: Finger]]
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[[Category: Wells PA]]
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[[Category: Hcv]]
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[[Category: Ns5b]]
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[[Category: Palm]]
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[[Category: Polymerase]]
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[[Category: Thumb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:42:07 2008''
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Current revision

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

PDB ID 1yvf

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