1t4w

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{{Seed}}
 
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[[Image:1t4w.png|left|200px]]
 
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==Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1==
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The line below this paragraph, containing "STRUCTURE_1t4w", creates the "Structure Box" on the page.
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<StructureSection load='1t4w' size='340' side='right'caption='[[1t4w]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T4W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1t4w| PDB=1t4w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4w OCA], [https://pdbe.org/1t4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t4w RCSB], [https://www.ebi.ac.uk/pdbsum/1t4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEP1_CAEEL CEP1_CAEEL] Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1.<ref>PMID:11696333</ref> <ref>PMID:11557844</ref> <ref>PMID:12445383</ref> <ref>PMID:15273685</ref> <ref>PMID:15707894</ref> <ref>PMID:15605074</ref> <ref>PMID:16319925</ref> <ref>PMID:17276923</ref> <ref>PMID:17186023</ref> <ref>PMID:17347667</ref> <ref>PMID:17895432</ref> <ref>PMID:18627611</ref> <ref>PMID:18836529</ref> <ref>PMID:19015549</ref>
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===Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1===
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==See Also==
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*[[P53 3D structures|P53 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15242600}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15242600 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15242600}}
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==About this Structure==
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1T4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4W OCA].
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==Reference==
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Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1., Huyen Y, Jeffrey PD, Derry WB, Rothman JH, Pavletich NP, Stavridi ES, Halazonetis TD, Structure. 2004 Jul;12(7):1237-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15242600 15242600]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Derry, W B.]]
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[[Category: Derry WB]]
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[[Category: Halazonetis, T D.]]
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[[Category: Halazonetis TD]]
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[[Category: Huyen, Y.]]
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[[Category: Huyen Y]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Pavletich, N P.]]
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[[Category: Pavletich NP]]
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[[Category: Rothman, J H.]]
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[[Category: Rothman JH]]
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[[Category: Stavridi, E S.]]
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[[Category: Stavridi ES]]
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[[Category: Dna-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:43:07 2008''
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Current revision

Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1

PDB ID 1t4w

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