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1psj

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(New page: 200px<br /><applet load="1psj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1psj, resolution 2.0&Aring;" /> '''ACIDIC PHOSPHOLIPASE ...)
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[[Image:1psj.gif|left|200px]]<br /><applet load="1psj" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1psj, resolution 2.0&Aring;" />
 
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'''ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS'''<br />
 
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==Overview==
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==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==
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The crystal structure of acidic phospholipase A2 from the venom of, Agkistrodon halys pallas has been determined by molecular replacement at, 2.0 A resolution to a crystallographic R-factor of 0.157. The overall, structure of the molecule is very similar to those of other phospholipase, A2 species of known structure. The catalytic site, the hydrophobic channel, and the N-terminal region show greatest structural conservation. The, Ca(2+)-binding region has a conformation that resembles closely that of, bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2, species, the conformation of the C-terminal ridge shows significant, difference due to the insertion of two residues. A unique aromatic patch, appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological, implications are discussed.
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<StructureSection load='1psj' size='340' side='right'caption='[[1psj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [https://pdbe.org/1psj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [https://www.ebi.ac.uk/pdbsum/1psj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1psj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psj ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1PSJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution., Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC, J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8636969 8636969]
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__TOC__
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</StructureSection>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
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[[Category: Phospholipase A(2)]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Lin ZJ]]
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[[Category: Lin, Z.J.]]
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[[Category: Wang XQ]]
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[[Category: Wang, X.Q.]]
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[[Category: CA]]
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[[Category: calcium]]
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[[Category: hydrolase]]
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[[Category: lipid degradation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:05:18 2007''
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Current revision

ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS

PDB ID 1psj

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