1oo2

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{{Seed}}
 
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[[Image:1oo2.png|left|200px]]
 
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==Crystal structure of transthyretin from Sparus aurata==
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The line below this paragraph, containing "STRUCTURE_1oo2", creates the "Structure Box" on the page.
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<StructureSection load='1oo2' size='340' side='right'caption='[[1oo2]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oo2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sparus_aurata Sparus aurata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OO2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_1oo2| PDB=1oo2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oo2 OCA], [https://pdbe.org/1oo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oo2 RCSB], [https://www.ebi.ac.uk/pdbsum/1oo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oo2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9PTT3_SPAAU Q9PTT3_SPAAU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/1oo2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oo2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol-specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Piscine TTR is shown here to exhibit high binding affinity for L-thyroxine and negligible affinity for RBP. The 1.56 A resolution X-ray structure of sea bream TTR, compared with that of human TTR, reveals a high degree of conservation of the thyroid hormone binding sites. In contrast, some amino acid differences in discrete regions of sea bream TTR appear to be responsible for the lack of protein-protein recognition, providing evidence for the crucial role played by a limited number of residues in the interaction between RBP and TTR. Overall, this study makes it possible to draw conclusions on evolutionary relationships for RBPs and TTRs of phylogenetically distant vertebrates.
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===Crystal structure of transthyretin from Sparus aurata===
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Distinctive binding and structural properties of piscine transthyretin.,Folli C, Pasquato N, Ramazzina I, Battistutta R, Zanotti G, Berni R FEBS Lett. 2003 Dec 4;555(2):279-84. PMID:14644428<ref>PMID:14644428</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1oo2" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14644428}}, adds the Publication Abstract to the page
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*[[Transthyretin 3D structures|Transthyretin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14644428 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14644428}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1OO2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sparus_aurata Sparus aurata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OO2 OCA].
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==Reference==
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Distinctive binding and structural properties of piscine transthyretin., Folli C, Pasquato N, Ramazzina I, Battistutta R, Zanotti G, Berni R, FEBS Lett. 2003 Dec 4;555(2):279-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14644428 14644428]
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[[Category: Single protein]]
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[[Category: Sparus aurata]]
[[Category: Sparus aurata]]
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[[Category: Battistutta, R.]]
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[[Category: Battistutta R]]
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[[Category: Berni, R.]]
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[[Category: Berni R]]
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[[Category: Folli, C.]]
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[[Category: Folli C]]
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[[Category: Pasquato, N.]]
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[[Category: Pasquato N]]
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[[Category: Ramazzina, I.]]
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[[Category: Ramazzina I]]
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[[Category: Zanotti, G.]]
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[[Category: Zanotti G]]
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[[Category: Retinol-binding protein]]
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[[Category: Tetramer]]
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[[Category: Transthyretin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:59:26 2008''
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Current revision

Crystal structure of transthyretin from Sparus aurata

PDB ID 1oo2

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