1x7b

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{{Seed}}
 
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[[Image:1x7b.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041==
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The line below this paragraph, containing "STRUCTURE_1x7b", creates the "Structure Box" on the page.
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<StructureSection load='1x7b' size='340' side='right'caption='[[1x7b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x7b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene></td></tr>
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{{STRUCTURE_1x7b| PDB=1x7b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [https://pdbe.org/1x7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB], [https://www.ebi.ac.uk/pdbsum/1x7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x7b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x7b ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041===
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==See Also==
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*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15548008 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15548008}}
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==About this Structure==
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1X7B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA].
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==Reference==
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Structure-based design of estrogen receptor-beta selective ligands., Manas ES, Unwalla RJ, Xu ZB, Malamas MS, Miller CP, Harris HA, Hsiao C, Akopian T, Hum WT, Malakian K, Wolfrom S, Bapat A, Bhat RA, Stahl ML, Somers WS, Alvarez JC, J Am Chem Soc. 2004 Nov 24;126(46):15106-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15548008 15548008]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Akopian, T.]]
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[[Category: Akopian T]]
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[[Category: Alvarez, J C.]]
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[[Category: Alvarez JC]]
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[[Category: Bapat, A.]]
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[[Category: Bapat A]]
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[[Category: Bhat, R A.]]
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[[Category: Bhat RA]]
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[[Category: Harris, H A.]]
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[[Category: Harris HA]]
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[[Category: Hsiao, C.]]
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[[Category: Hsiao C]]
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[[Category: Hum, W T.]]
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[[Category: Hum WT]]
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[[Category: Malakian, K.]]
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[[Category: Malakian K]]
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[[Category: Malamas, M S.]]
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[[Category: Malamas MS]]
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[[Category: Manas, E S.]]
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[[Category: Manas ES]]
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[[Category: Miller, C P.]]
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[[Category: Miller CP]]
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[[Category: Somers, W S.]]
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[[Category: Somers WS]]
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[[Category: Stahl, M L.]]
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[[Category: Stahl ML]]
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[[Category: Unwalla, R J.]]
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[[Category: Unwalla RJ]]
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[[Category: Wolfrom, S.]]
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[[Category: Wolfrom S]]
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[[Category: Xu, Z B.]]
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[[Category: Xu ZB]]
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[[Category: Agonist]]
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[[Category: Er]]
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[[Category: Er-beta]]
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[[Category: Estrogen]]
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[[Category: Estrogen receptor]]
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[[Category: Estrogen receptor beta]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:06:32 2008''
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Current revision

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041

PDB ID 1x7b

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