This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bdn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:24, 3 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2bdn.png|left|200px]]
 
-
<!--
+
==Crystal structure of human MCP-1 bound to a blocking antibody, 11K2==
-
The line below this paragraph, containing "STRUCTURE_2bdn", creates the "Structure Box" on the page.
+
<StructureSection load='2bdn' size='340' side='right'caption='[[2bdn]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2bdn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdn OCA], [https://pdbe.org/2bdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdn RCSB], [https://www.ebi.ac.uk/pdbsum/2bdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdn ProSAT]</span></td></tr>
-
{{STRUCTURE_2bdn| PDB=2bdn | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bdn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bdn ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of human MCP-1 bound to a blocking antibody, 11K2===
+
==See Also==
-
 
+
*[[Antibody 3D structures|Antibody 3D structures]]
-
 
+
*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
-
<!--
+
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16682434}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16682434 is the PubMed ID number.
+
</StructureSection>
-
-->
+
[[Category: Homo sapiens]]
-
{{ABSTRACT_PUBMED_16682434}}
+
[[Category: Large Structures]]
-
 
+
-
==About this Structure==
+
-
2BDN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDN OCA].
+
-
 
+
-
==Reference==
+
-
Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody., Reid C, Rushe M, Jarpe M, van Vlijmen H, Dolinski B, Qian F, Cachero TG, Cuervo H, Yanachkova M, Nwankwo C, Wang X, Etienne N, Garber E, Bailly V, de Fougerolles A, Boriack-Sjodin PA, Protein Eng Des Sel. 2006 Jul;19(7):317-24. Epub 2006 May 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16682434 16682434]
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Bailly V]]
-
[[Category: Bailly, V.]]
+
[[Category: Boriack-Sjodin PA]]
-
[[Category: Boriack-Sjodin, P A.]]
+
[[Category: Jarpe M]]
-
[[Category: Jarpe, M]]
+
[[Category: Reid C]]
-
[[Category: Reid, C.]]
+
[[Category: Rushe M]]
-
[[Category: Rushe, M.]]
+
[[Category: Van Vlijmen H]]
-
[[Category: Vlijmen, Hvan.]]
+
-
[[Category: Antibody-antigen complex]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:07:15 2008''
+

Current revision

Crystal structure of human MCP-1 bound to a blocking antibody, 11K2

PDB ID 2bdn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bdn"
Personal tools