3bji

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{{Seed}}
 
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[[Image:3bji.png|left|200px]]
 
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==Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1==
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The line below this paragraph, containing "STRUCTURE_3bji", creates the "Structure Box" on the page.
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<StructureSection load='3bji' size='340' side='right'caption='[[3bji]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bji]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BJI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3bji| PDB=3bji | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bji OCA], [https://pdbe.org/3bji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bji RCSB], [https://www.ebi.ac.uk/pdbsum/3bji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bji ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bj/3bji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bji ConSurf].
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<div style="clear:both"></div>
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===Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1===
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==See Also==
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*[[Rac 3D structures|Rac 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18589439}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18589439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18589439}}
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==About this Structure==
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3BJI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BJI OCA].
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==Reference==
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Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1., Chrencik JE, Brooun A, Zhang H, Mathews II, Hura GL, Foster SA, Perry JJ, Streiff M, Ramage P, Widmer H, Bokoch GM, Tainer JA, Weckbecker G, Kuhn P, J Mol Biol. 2008 Jul 25;380(5):828-43. Epub 2008 May 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18589439 18589439]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Brooun, A.]]
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[[Category: Brooun A]]
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[[Category: Chrencik, J E.]]
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[[Category: Chrencik JE]]
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[[Category: Kuhn, P.]]
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[[Category: Kuhn P]]
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[[Category: Adp-ribosylation]]
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[[Category: Alternative splicing]]
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[[Category: Atypical cysteine rich domain]]
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[[Category: Gef/gtpase]]
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[[Category: Gtp-binding]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nucleotide-binding]]
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[[Category: Phorbol-ester binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Prenylation]]
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[[Category: Protein-protein interaction]]
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[[Category: Proto-oncogene]]
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[[Category: Sh2 domain]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:21:04 2008''
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Current revision

Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1

PDB ID 3bji

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