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1sq6

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{{Seed}}
 
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[[Image:1sq6.png|left|200px]]
 
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==Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase==
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The line below this paragraph, containing "STRUCTURE_1sq6", creates the "Structure Box" on the page.
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<StructureSection load='1sq6' size='340' side='right'caption='[[1sq6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sq6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1sq6| PDB=1sq6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq6 OCA], [https://pdbe.org/1sq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq6 ProSAT]</span></td></tr>
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</table>
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===Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase===
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== Function ==
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[https://www.uniprot.org/uniprot/PNPH_PLAF7 PNPH_PLAF7] As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:18957439, PubMed:14982926, PubMed:16131758, PubMed:19575810, PubMed:24416224, PubMed:29440412). Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Generates hypoxanthine from both the purine salvage pathway and from polyamine metabolism which is required for nucleic acids synthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Has no activity towards adenosine (By similarity).[UniProtKB:Q8T9Z7]<ref>PMID:14982926</ref> <ref>PMID:16131758</ref> <ref>PMID:18957439</ref> <ref>PMID:19575810</ref> <ref>PMID:24416224</ref> <ref>PMID:29440412</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16131758}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16131758 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16131758}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1SQ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine., Schnick C, Robien MA, Brzozowski AM, Dodson EJ, Murshudov GN, Anderson L, Luft JR, Mehlin C, Hol WG, Brannigan JA, Wilkinson AJ, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1245-54. Epub 2005, Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16131758 16131758]
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<references/>
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[[Category: Plasmodium falciparum 3d7]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Uridine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Hol, W G.J.]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Robien, M A.]]
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[[Category: Hol WGJ]]
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[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
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[[Category: Robien MA]]
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[[Category: Alpha+beta]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Sgpp]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics of pathogenic protozoa consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:59:18 2008''
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Current revision

Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase

PDB ID 1sq6

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