2ftb

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{{Seed}}
 
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[[Image:2ftb.png|left|200px]]
 
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==Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to oleic acid==
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The line below this paragraph, containing "STRUCTURE_2ftb", creates the "Structure Box" on the page.
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<StructureSection load='2ftb' size='340' side='right'caption='[[2ftb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ftb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ambystoma_mexicanum Ambystoma mexicanum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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{{STRUCTURE_2ftb| PDB=2ftb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftb OCA], [https://pdbe.org/2ftb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftb RCSB], [https://www.ebi.ac.uk/pdbsum/2ftb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABP2_AMBME FABP2_AMBME] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). The specificity of axolotl L-FABP differs from that of LB-FABP. Binds 2 ligands per protein molecule.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The family of the liver bile acid-binding proteins (L-BABPs), formerly called liver basic fatty acid-binding proteins (Lb-FABPs) shares fold and sequence similarity with the paralogous liver fatty acid-binding proteins (L-FABPs) but has a different stoichiometry and specificity of ligand binding. This article describes the first X-ray structure of a member of the L-BABP family, axolotl (Ambystoma mexicanum) L-BABP, bound to two different ligands: cholic and oleic acid. The protein binds one molecule of oleic acid in a position that is significantly different from that of either of the two molecules that bind to rat liver FABP. The stoichiometry of binding of cholate is of two ligands per protein molecule, as observed in chicken L-BABP. The cholate molecule that binds buried most deeply into the internal cavity overlaps well with the analogous bound to chicken L-BABP, whereas the second molecule, which interacts with the first only through hydrophobic contacts, is more external and exposed to the solvent.
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===Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to oleic acid===
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Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to cholic and oleic acid.,Capaldi S, Guariento M, Perduca M, Di Pietro SM, Santome JA, Monaco HL Proteins. 2006 Jul 1;64(1):79-88. PMID:16555310<ref>PMID:16555310</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ftb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16555310}}, adds the Publication Abstract to the page
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16555310 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16555310}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2FTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ambystoma_mexicanum Ambystoma mexicanum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTB OCA].
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==Reference==
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Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to cholic and oleic acid., Capaldi S, Guariento M, Perduca M, Di Pietro SM, Santome JA, Monaco HL, Proteins. 2006 Jul 1;64(1):79-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16555310 16555310]
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Crystallization and preliminary X-ray study of two liver basic fatty acid-binding proteins., Di Pietro SM, Perduca M, Santome JA, Monaco HL, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1903-5. Epub 2001, Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11717512 11717512]
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[[Category: Ambystoma mexicanum]]
[[Category: Ambystoma mexicanum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Capaldi, S.]]
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[[Category: Capaldi S]]
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[[Category: Guariento, M.]]
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[[Category: Di Pietro SM]]
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[[Category: Monaco, H L.]]
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[[Category: Guariento M]]
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[[Category: Perduca, M.]]
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[[Category: Monaco HL]]
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[[Category: Pietro, S M.Di.]]
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[[Category: Perduca M]]
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[[Category: Santome, J A.]]
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[[Category: Santome JA]]
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[[Category: Axolotl]]
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[[Category: Babp]]
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[[Category: Lb-fabp]]
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[[Category: Liver basic fatty acid-binding protein]]
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[[Category: Liver bile acid-binding protein]]
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[[Category: Oleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:00:25 2008''
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Current revision

Crystal structure of axolotl (Ambystoma mexicanum) liver bile acid-binding protein bound to oleic acid

PDB ID 2ftb

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