1qdl

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{{Seed}}
 
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[[Image:1qdl.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF ANTHRANILATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS==
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The line below this paragraph, containing "STRUCTURE_1qdl", creates the "Structure Box" on the page.
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<StructureSection load='1qdl' size='340' side='right'caption='[[1qdl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qdl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QDL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdl OCA], [https://pdbe.org/1qdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qdl RCSB], [https://www.ebi.ac.uk/pdbsum/1qdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qdl ProSAT]</span></td></tr>
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{{STRUCTURE_1qdl| PDB=1qdl | SCENE= }}
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</table>
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== Function ==
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===THE CRYSTAL STRUCTURE OF ANTHRANILATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS===
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[https://www.uniprot.org/uniprot/TRPE_SACS2 TRPE_SACS2] Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.<ref>PMID:10449718</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10449718}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qdl ConSurf].
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1QDL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDL OCA].
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== References ==
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==Reference==
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<references/>
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The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications., Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN, Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9479-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10449718 10449718]
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__TOC__
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[[Category: Anthranilate synthase]]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Bauerle, R.]]
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[[Category: Bauerle R]]
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[[Category: Gonzalez, A.]]
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[[Category: Gonzalez A]]
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[[Category: Hester, G.]]
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[[Category: Hester G]]
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[[Category: Ivens, A.]]
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[[Category: Ivens A]]
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[[Category: Jansonius, J N.]]
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[[Category: Jansonius JN]]
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[[Category: Kirschner, K.]]
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[[Category: Kirschner K]]
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[[Category: Knoechel, T.]]
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[[Category: Knoechel T]]
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[[Category: Wilmanns, M.]]
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[[Category: Wilmanns M]]
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[[Category: Allosteric interaction]]
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[[Category: Anthranilate synthase]]
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[[Category: Glutamine amidotransferase]]
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[[Category: Tryptophan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:03:19 2008''
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Current revision

THE CRYSTAL STRUCTURE OF ANTHRANILATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS

PDB ID 1qdl

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