2paw

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{{Seed}}
 
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[[Image:2paw.png|left|200px]]
 
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==THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE==
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The line below this paragraph, containing "STRUCTURE_2paw", creates the "Structure Box" on the page.
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<StructureSection load='2paw' size='340' side='right'caption='[[2paw]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2paw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1paw 1paw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PAW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2paw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2paw OCA], [https://pdbe.org/2paw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2paw RCSB], [https://www.ebi.ac.uk/pdbsum/2paw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2paw ProSAT]</span></td></tr>
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{{STRUCTURE_2paw| PDB=2paw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_CHICK PARP1_CHICK] Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/2paw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2paw ConSurf].
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<div style="clear:both"></div>
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===THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE===
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9521710}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9521710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9521710}}
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==About this Structure==
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2PAW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1paw 1paw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PAW OCA].
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==Reference==
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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling., Ruf A, de Murcia G, Schulz GE, Biochemistry. 1998 Mar 17;37(11):3893-900. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9521710 9521710]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ruf, A.]]
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[[Category: Ruf A]]
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[[Category: Schulz, G E.]]
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[[Category: Schulz GE]]
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[[Category: Dna-binding]]
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[[Category: Glycosyltransferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:08:08 2008''
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Current revision

THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE

PDB ID 2paw

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