1qtg

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{{Seed}}
 
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[[Image:1qtg.png|left|200px]]
 
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==AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR==
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The line below this paragraph, containing "STRUCTURE_1qtg", creates the "Structure Box" on the page.
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<StructureSection load='1qtg' size='340' side='right'caption='[[1qtg]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qtg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_virus_P22 Salmonella virus P22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtg OCA], [https://pdbe.org/1qtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtg RCSB], [https://www.ebi.ac.uk/pdbsum/1qtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtg ProSAT]</span></td></tr>
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{{STRUCTURE_1qtg| PDB=1qtg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RARC_BPP22 RARC_BPP22] This protein acts as a transcriptional repressor of its own gene arc and of gene ant.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A "switch" mutant of the Arc repressor homodimer was constructed by interchanging the sequence positions of a hydrophobic core residue, leucine 12, and an adjacent surface polar residue, asparagine 11, in each strand of an intersubunit beta sheet. The mutant protein adopts a fold in which each beta strand is replaced by a right-handed helix and side chains in this region undergo significant repacking. The observed structural changes allow the protein to maintain solvent exposure of polar side chains and optimal burial of hydrophobic side chains. These results suggest that new protein folds can evolve from existing folds without drastic or large-scale mutagenesis.
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===AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR===
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Evolution of a protein fold in vitro.,Cordes MH, Walsh NP, McKnight CJ, Sauer RT Science. 1999 Apr 9;284(5412):325-8. PMID:10195898<ref>PMID:10195898</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10195898}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qtg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10195898 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10195898}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1QTG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTG OCA].
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[[Category: Salmonella virus P22]]
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[[Category: Cordes MHJ]]
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==Reference==
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[[Category: McKnight CJ]]
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Evolution of a protein fold in vitro., Cordes MH, Walsh NP, McKnight CJ, Sauer RT, Science. 1999 Apr 9;284(5412):325-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10195898 10195898]
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[[Category: Sauer RT]]
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[[Category: Enterobacteria phage p22]]
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[[Category: Walsh NP]]
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[[Category: Single protein]]
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[[Category: Cordes, M H.J.]]
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[[Category: McKnight, C J.]]
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[[Category: Sauer, R T.]]
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[[Category: Walsh, N P.]]
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[[Category: Beta-sheet]]
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[[Category: Right-handed helix]]
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[[Category: Structural change]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:11:14 2008''
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Current revision

AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR

PDB ID 1qtg

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