1t6g

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{{Seed}}
 
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[[Image:1t6g.png|left|200px]]
 
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==Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I==
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The line below this paragraph, containing "STRUCTURE_1t6g", creates the "Structure Box" on the page.
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<StructureSection load='1t6g' size='340' side='right'caption='[[1t6g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t6g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger] and [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_1t6g| PDB=1t6g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6g OCA], [https://pdbe.org/1t6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6g RCSB], [https://www.ebi.ac.uk/pdbsum/1t6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8H0K8_WHEAT Q8H0K8_WHEAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t6g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plants developed a diverse battery of defense mechanisms in response to continual challenges by a broad spectrum of pathogenic microorganisms. Their defense arsenal includes inhibitors of cell wall-degrading enzymes, which hinder a possible invasion and colonization by antagonists. The structure of Triticum aestivum xylanase inhibitor-I (TAXI-I), a first member of potent TAXI-type inhibitors of fungal and bacterial family 11 xylanases, has been determined to 1.7-A resolution. Surprisingly, TAXI-I displays structural homology with the pepsin-like family of aspartic proteases but is proteolytically nonfunctional, because one or more residues of the essential catalytical triad are absent. The structure of the TAXI-I.Aspergillus niger xylanase I complex, at a resolution of 1.8 A, illustrates the ability of tight binding and inhibition with subnanomolar affinity and indicates the importance of the C-terminal end for the differences in xylanase specificity among different TAXI-type inhibitors.
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===Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I===
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Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I.,Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA, Rabijns A J Biol Chem. 2004 Aug 20;279(34):36022-8. Epub 2004 May 27. PMID:15166216<ref>PMID:15166216</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15166216}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1t6g" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15166216 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15166216}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1T6G is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Aspergillus_niger Aspergillus niger] and [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6G OCA].
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==Reference==
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Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I., Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA, Rabijns A, J Biol Chem. 2004 Aug 20;279(34):36022-8. Epub 2004 May 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15166216 15166216]
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[[Category: Aspergillus niger]]
[[Category: Aspergillus niger]]
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[[Category: Endo-1,4-beta-xylanase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Triticum aestivum]]
[[Category: Triticum aestivum]]
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[[Category: Brijs, K.]]
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[[Category: Brijs K]]
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[[Category: Courtin, C M.]]
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[[Category: Courtin CM]]
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[[Category: Delcour, J A.]]
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[[Category: De Ranter CJ]]
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[[Category: Gebruers, K.]]
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[[Category: Delcour JA]]
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[[Category: Rabijns, A.]]
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[[Category: Gebruers K]]
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[[Category: Ranter, C J.De.]]
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[[Category: Rabijns A]]
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[[Category: Sansen, S.]]
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[[Category: Sansen S]]
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[[Category: Beta-jelly roll structure]]
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[[Category: Protein-protein complex]]
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[[Category: Two beta-barrel domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:15:14 2008''
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Current revision

Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I

PDB ID 1t6g

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