1x26

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{{Seed}}
 
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[[Image:1x26.png|left|200px]]
 
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==Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone==
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The line below this paragraph, containing "STRUCTURE_1x26", creates the "Structure Box" on the page.
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<StructureSection load='1x26' size='340' side='right'caption='[[1x26]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x26]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X26 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAZ:N~3~-{3-[(7-METHYL-1,8-NAPHTHYRIDIN-2-YL)AMINO]-3-OXOPROPYL}-N~1~-[(7-OXO-7,8-DIHYDRO-1,8-NAPHTHYRIDIN-2-YL)METHYL]-BETA-ALANINAMIDE'>NAZ</scene></td></tr>
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{{STRUCTURE_1x26| PDB=1x26 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x26 OCA], [https://pdbe.org/1x26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x26 RCSB], [https://www.ebi.ac.uk/pdbsum/1x26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x26 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA trinucleotide repeats, particularly CXG, are common within the human genome. However, expansion of trinucleotide repeats is associated with a number of disorders, including Huntington disease, spinobulbar muscular atrophy and spinocerebellar ataxia. In these cases, the repeat length is known to correlate with decreased age of onset and disease severity. Repeat expansion of (CAG)n, (CTG)n and (CGG)n trinucleotides may be related to the increased stability of alternative DNA hairpin structures consisting of CXG-CXG triads with X-X mismatches. Small-molecule ligands that selectively bound to CAG repeats could provide an important probe for determining repeat length and an important tool for investigating the in vivo repeat extension mechanism. Here we report that napthyridine-azaquinolone (NA, 1) is a ligand for CAG repeats and can be used as a diagnostic tool for determining repeat length. We show by NMR spectroscopy that binding of NA to CAG repeats induces the extrusion of a cytidine nucleotide from the DNA helix.
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===Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone===
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Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.,Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C Nat Chem Biol. 2005 Jun;1(1):39-43. Epub 2005 May 24. PMID:16407992<ref>PMID:16407992</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16407992}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1x26" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16407992 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16407992}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1X26 is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X26 OCA].
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[[Category: Goto Y]]
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[[Category: Hagihara M]]
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==Reference==
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[[Category: Hagihara S]]
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Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats., Nakatani K, Hagihara S, Goto Y, Kobori A, Hagihara M, Hayashi G, Kyo M, Nomura M, Mishima M, Kojima C, Nat Chem Biol. 2005 Jun;1(1):39-43. Epub 2005 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16407992 16407992]
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[[Category: Hayashi G]]
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[[Category: Protein complex]]
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[[Category: Kobori A]]
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[[Category: Goto, Y.]]
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[[Category: Kojima C]]
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[[Category: Hagihara, M.]]
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[[Category: Kyo M]]
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[[Category: Hagihara, S.]]
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[[Category: Mishima M]]
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[[Category: Hayashi, G.]]
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[[Category: Nakatani K]]
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[[Category: Kobori, A.]]
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[[Category: Nomura M]]
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[[Category: Kojima, C.]]
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[[Category: Kyo, M.]]
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[[Category: Mishima, M.]]
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[[Category: Nakatani, K.]]
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[[Category: Nomura, M.]]
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[[Category: Aa mismatch]]
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[[Category: Dna]]
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[[Category: Drug]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:20:32 2008''
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Current revision

Solution structure of the AA-mismatch DNA complexed with naphthyridine-azaquinolone

PDB ID 1x26

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