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2dsb

From Proteopedia

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{{Seed}}
 
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[[Image:2dsb.png|left|200px]]
 
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==Crystal structure of human ADP-ribose pyrophosphatase NUDT5==
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The line below this paragraph, containing "STRUCTURE_2dsb", creates the "Structure Box" on the page.
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<StructureSection load='2dsb' size='340' side='right'caption='[[2dsb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsb OCA], [https://pdbe.org/2dsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsb RCSB], [https://www.ebi.ac.uk/pdbsum/2dsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsb ProSAT]</span></td></tr>
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{{STRUCTURE_2dsb| PDB=2dsb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUDT5_HUMAN NUDT5_HUMAN] Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.<ref>PMID:17052728</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsb ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human ADP-ribose pyrophosphatase NUDT5===
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==See Also==
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*[[ADP-ribose pyrophosphatase 3D structures|ADP-ribose pyrophosphatase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17052728}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17052728 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17052728}}
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==About this Structure==
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2DSB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSB OCA].
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==Reference==
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Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity., Zha M, Zhong C, Peng Y, Hu H, Ding J, J Mol Biol. 2006 Dec 15;364(5):1021-33. Epub 2006 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17052728 17052728]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ding, J.]]
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[[Category: Ding J]]
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[[Category: Zha, M.]]
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[[Category: Zha M]]
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[[Category: Zhong, C.]]
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[[Category: Zhong C]]
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[[Category: Adp-ribose pyrophosphatase]]
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[[Category: Adpr]]
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[[Category: Nudix domain]]
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[[Category: Nudt5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:21:19 2008''
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Current revision

Crystal structure of human ADP-ribose pyrophosphatase NUDT5

PDB ID 2dsb

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