3cei

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{{Seed}}
 
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[[Image:3cei.png|left|200px]]
 
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==Crystal Structure of Superoxide Dismutase from Helicobacter pylori==
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The line below this paragraph, containing "STRUCTURE_3cei", creates the "Structure Box" on the page.
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<StructureSection load='3cei' size='340' side='right'caption='[[3cei]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CEI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3cei| PDB=3cei | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cei OCA], [https://pdbe.org/3cei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cei RCSB], [https://www.ebi.ac.uk/pdbsum/3cei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cei ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SODF_HELPY SODF_HELPY] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3cei_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cei ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Superoxide dismutases (SODs) are key enzymes for fighting oxidative stress. Helicobacter pylori produces a single SOD (HpSOD) which contains iron. The structure of this antioxidant protein has been determined at 2.4 A resolution. It is a dimer of two identical subunits with one iron ion per monomer. The protein shares 53% sequence identity with the corresponding enzyme from Escherichia coli. The model is compared with those of other dimeric Fe-containing SODs. HpSOD shows significant differences in relation to other SODs, the most important being an extended C-terminal tail. This structure provides a model for closely related sequences from species such as Campylobacter, where no structures are currently known. The structure of extended carboxyl termini is discussed in light of putative functions it may serve.
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===Crystal Structure of Superoxide Dismutase from Helicobacter pylori===
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The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension.,Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari A Biochim Biophys Acta. 2008 Nov;1784(11):1601-6. Epub 2008 May 6. PMID:18502213<ref>PMID:18502213</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3cei" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18502213}}, adds the Publication Abstract to the page
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18502213 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18502213}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3CEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEI OCA].
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==Reference==
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The crystal structure of the superoxide dismutase from Helicobacter pylori reveals a structured C-terminal extension., Esposito L, Seydel A, Aiello R, Sorrentino G, Cendron L, Zanotti G, Zagari A, Biochim Biophys Acta. 2008 May 6;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18502213 18502213]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Superoxide dismutase]]
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[[Category: Aiello R]]
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[[Category: Aiello, R.]]
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[[Category: Cendron L]]
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[[Category: Cendron, L.]]
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[[Category: Esposito L]]
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[[Category: Esposito, L.]]
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[[Category: Seydel A]]
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[[Category: Seydel, A.]]
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[[Category: Sorrentino G]]
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[[Category: Sorrentino, G.]]
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[[Category: Zagari A]]
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[[Category: Zagari, A.]]
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[[Category: Zanotti G]]
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[[Category: Zanotti, G.]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:39:27 2008''
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Current revision

Crystal Structure of Superoxide Dismutase from Helicobacter pylori

PDB ID 3cei

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