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2r40

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{{Seed}}
 
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[[Image:2r40.png|left|200px]]
 
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<!--
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==Crystal structure of 20E bound EcR/USP==
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The line below this paragraph, containing "STRUCTURE_2r40", creates the "Structure Box" on the page.
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<StructureSection load='2r40' size='340' side='right'caption='[[2r40]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Heliothis_virescens Heliothis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R40 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.402&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20E:(2BETA,3BETA,5BETA,22R)-2,3,14,20,22,25-HEXAHYDROXYCHOLEST-7-EN-6-ONE'>20E</scene>, <scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2r40| PDB=2r40 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r40 OCA], [https://pdbe.org/2r40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r40 RCSB], [https://www.ebi.ac.uk/pdbsum/2r40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r40 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of 20E bound EcR/USP===
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== Function ==
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[https://www.uniprot.org/uniprot/ECR_HELVI ECR_HELVI] Receptor for ecdysone. Binds to ecdysone response elements (ECRES) (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17848566}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17848566 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r40_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17848566}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2R40 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Heliothis_virescens Heliothis virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R40 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r40 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Critical role of desolvation in the binding of 20-hydroxyecdysone to the ecdysone receptor., Browning C, Martin E, Loch C, Wurtz JM, Moras D, Stote RH, Dejaegere AP, Billas IM, J Biol Chem. 2007 Nov 9;282(45):32924-34. Epub 2007 Sep 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17848566 17848566]
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</StructureSection>
[[Category: Heliothis virescens]]
[[Category: Heliothis virescens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Billas, I M.L.]]
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[[Category: Billas IML]]
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[[Category: Browning, C.]]
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[[Category: Browning C]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Anti-parallel alpha-helical sandwich]]
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[[Category: Ecdysone receptor]]
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[[Category: Ecr]]
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[[Category: Gene regulation]]
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[[Category: Nuclear receptor ligand-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:40:17 2008''
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Current revision

Crystal structure of 20E bound EcR/USP

PDB ID 2r40

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