2rer

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{{Seed}}
 
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[[Image:2rer.png|left|200px]]
 
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==Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens==
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The line below this paragraph, containing "STRUCTURE_2rer", creates the "Structure Box" on the page.
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<StructureSection load='2rer' size='340' side='right'caption='[[2rer]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rer]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RER FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rer OCA], [https://pdbe.org/2rer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rer RCSB], [https://www.ebi.ac.uk/pdbsum/2rer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rer ProSAT]</span></td></tr>
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{{STRUCTURE_2rer| PDB=2rer | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens===
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[https://www.uniprot.org/uniprot/TCMN_STRGA TCMN_STRGA] The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomycin D3 (Tcm D3) to yield Tcm B3. Catalyzes as well the following side reactions: methylation of 8-O-methyl-Tcm D3 to yield Tcm E; and of 9-carboxymethyl-Tcm B3 to yield Tcm A2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_18388203}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 18388203 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rer_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_18388203}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rer ConSurf].
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2RER is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_glaucescens Streptomyces glaucescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RER OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides., Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC, Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5349-54. Epub 2008 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18388203 18388203]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Streptomyces glaucescens]]
[[Category: Streptomyces glaucescens]]
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[[Category: Ames, B D.]]
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[[Category: Ames BD]]
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[[Category: Korman, T P.]]
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[[Category: Korman TP]]
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[[Category: Tsai, S C.]]
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[[Category: Tsai SC]]
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[[Category: Vu, T N.]]
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[[Category: Vu TN]]
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[[Category: Antibiotic]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Anticancer]]
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[[Category: Aromatase]]
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[[Category: Biosynthetic protein]]
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[[Category: Cyclase]]
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[[Category: Dehydratase]]
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[[Category: Helix-grip]]
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[[Category: Methyltransferase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Polyketide]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:45:46 2008''
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Current revision

Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens

PDB ID 2rer

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