1vit

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{{Seed}}
 
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[[Image:1vit.png|left|200px]]
 
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==THROMBIN:HIRUDIN 51-65 COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1vit", creates the "Structure Box" on the page.
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<StructureSection load='1vit' size='340' side='right'caption='[[1vit]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vit]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VIT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1vit| PDB=1vit | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vit OCA], [https://pdbe.org/1vit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vit RCSB], [https://www.ebi.ac.uk/pdbsum/1vit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vit ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/1vit_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vit ConSurf].
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<div style="clear:both"></div>
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===THROMBIN:HIRUDIN 51-65 COMPLEX===
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==See Also==
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*[[Hirudin 3D structures|Hirudin 3D structures]]
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*[[Thrombin 3D Structures|Thrombin 3D Structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_15299666}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15299666 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299666}}
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==About this Structure==
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1VIT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIT OCA].
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==Reference==
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Structure of a bovine thrombin-hirudin51-65 complex determined by a combination of molecular replacement and graphics. Incorporation of known structural information in molecular replacement., Vitali J, Martin PD, Malkowski MG, Olsen CM, Johnson PH, Edwards BF, Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):453-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299666 15299666]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Thrombin]]
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[[Category: Edwards BFP]]
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[[Category: Edwards, B F.P.]]
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[[Category: Vitali J]]
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[[Category: Vitali, J.]]
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[[Category: Blood coagulation]]
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[[Category: Hydrolase]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:00:20 2008''
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Current revision

THROMBIN:HIRUDIN 51-65 COMPLEX

PDB ID 1vit

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