1u81

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{{Seed}}
 
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[[Image:1u81.png|left|200px]]
 
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==Delta-17 Human ADP Ribosylation Factor 1 Complexed with GDP==
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The line below this paragraph, containing "STRUCTURE_1u81", creates the "Structure Box" on the page.
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<StructureSection load='1u81' size='340' side='right'caption='[[1u81]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U81 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1u81| PDB=1u81 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u81 OCA], [https://pdbe.org/1u81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u81 RCSB], [https://www.ebi.ac.uk/pdbsum/1u81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u81 ProSAT]</span></td></tr>
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</table>
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===Delta-17 Human ADP Ribosylation Factor 1 Complexed with GDP===
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== Function ==
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[https://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15308674 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u8/1u81_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15308674}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1U81 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U81 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u81 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements., Seidel RD 3rd, Amor JC, Kahn RA, Prestegard JH, J Biol Chem. 2004 Nov 12;279(46):48307-18. Epub 2004 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15308674 15308674]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Amor, J C.]]
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[[Category: Amor JC]]
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[[Category: III, R D.Seidel.]]
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[[Category: Kahn RA]]
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[[Category: Kahn, R A.]]
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[[Category: Prestegard JH]]
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[[Category: Prestegard, J H.]]
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[[Category: Seidel RD]]
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[[Category: Arf1]]
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[[Category: D17arf1]]
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[[Category: Delta17arf1]]
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[[Category: Gdp-binding]]
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[[Category: Membrane trafficking]]
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[[Category: Rdc refinement]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:04:59 2008''
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Current revision

Delta-17 Human ADP Ribosylation Factor 1 Complexed with GDP

PDB ID 1u81

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