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1ovb

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{{Seed}}
 
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[[Image:1ovb.png|left|200px]]
 
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==THE MECHANISM OF IRON UPTAKE BY TRANSFERRINS: THE STRUCTURE OF AN 18KD NII-DOMAIN FRAGMENT AT 2.3 ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_1ovb", creates the "Structure Box" on the page.
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<StructureSection load='1ovb' size='340' side='right'caption='[[1ovb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ovb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_sp. Anas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OVB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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{{STRUCTURE_1ovb| PDB=1ovb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ovb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ovb OCA], [https://pdbe.org/1ovb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ovb RCSB], [https://www.ebi.ac.uk/pdbsum/1ovb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ovb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_ANAPL TRFE_ANAPL] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Ovotransferrin has a bacteriostatic function. Its concentration in avian egg is the highest concentration of any transferrin in vivo (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/1ovb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ovb ConSurf].
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<div style="clear:both"></div>
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===THE MECHANISM OF IRON UPTAKE BY TRANSFERRINS: THE STRUCTURE OF AN 18KD NII-DOMAIN FRAGMENT AT 2.3 ANGSTROMS RESOLUTION===
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==See Also==
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15299534}}, adds the Publication Abstract to the page
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[[Category: Anas sp]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15299534 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Kuser P]]
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{{ABSTRACT_PUBMED_15299534}}
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[[Category: Lindley P]]
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[[Category: Sarra R]]
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==About this Structure==
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1OVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anas_sp. Anas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVB OCA].
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==Reference==
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The mechanism of iron uptake by transferrins: the structure of an 18 kDa NII-domain fragment from duck ovotransferrin at 2.3 A resolution., Lindley PF, Bajaj M, Evans RW, Garratt RC, Hasnain SS, Jhoti H, Kuser P, Neu M, Patel K, Sarra R, Strange R, Walton A, Acta Crystallogr D Biol Crystallogr. 1993 Mar 1;49(Pt 2):292-304. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299534 15299534]
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[[Category: Anas sp.]]
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[[Category: Single protein]]
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[[Category: Kuser, P.]]
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[[Category: Lindley, P.]]
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[[Category: Sarra, R.]]
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[[Category: Iron transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:12:55 2008''
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Current revision

THE MECHANISM OF IRON UPTAKE BY TRANSFERRINS: THE STRUCTURE OF AN 18KD NII-DOMAIN FRAGMENT AT 2.3 ANGSTROMS RESOLUTION

PDB ID 1ovb

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