1qoy

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{{Seed}}
 
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[[Image:1qoy.png|left|200px]]
 
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==E.coli Hemolysin E (HlyE, ClyA, SheA)==
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The line below this paragraph, containing "STRUCTURE_1qoy", creates the "Structure Box" on the page.
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<StructureSection load='1qoy' size='340' side='right'caption='[[1qoy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qoy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1qoy| PDB=1qoy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoy OCA], [https://pdbe.org/1qoy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qoy RCSB], [https://www.ebi.ac.uk/pdbsum/1qoy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qoy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HLYE_ECOLI HLYE_ECOLI] Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.<ref>PMID:14532000</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. Here we report the X-ray crystal structure of the water-soluble form of E. coli HlyE at 2.0 A resolution and the visualization of the lipid-associated form of the toxin in projection at low resolution by electron microscopy. The crystal structure reveals HlyE to be the first member of a new family of toxin structures, consisting of an elaborated helical bundle some 100 A long. The electron micrographs show how HlyE oligomerizes in the presence of lipid to form transmembrane pores. Taken together, the data from these two structural techniques allow us to propose a simple model for the structure of the pore and for membrane interaction.
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===E.COLI HEMOLYSIN E (HLYE, CLYA, SHEA)===
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E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy.,Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ Cell. 2000 Jan 21;100(2):265-76. PMID:10660049<ref>PMID:10660049</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qoy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10660049}}, adds the Publication Abstract to the page
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10660049 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10660049}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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1QOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOY OCA].
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[[Category: Large Structures]]
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[[Category: Artymiuk PJ]]
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==Reference==
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[[Category: Atkins A]]
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E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy., Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ, Cell. 2000 Jan 21;100(2):265-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10660049 10660049]
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[[Category: Bullough PA]]
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[[Category: Escherichia coli]]
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[[Category: Green J]]
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[[Category: Single protein]]
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[[Category: Jamieson SJ]]
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[[Category: Artymiuk, P J.]]
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[[Category: Stillman TJ]]
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[[Category: Atkins, A.]]
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[[Category: Wallace AJ]]
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[[Category: Bullough, P A.]]
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[[Category: Green, J.]]
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[[Category: Jamieson, S J.]]
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[[Category: Stillman, T J.]]
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[[Category: Wallace, A J.]]
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[[Category: Cytolysin]]
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[[Category: Hemolysin]]
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[[Category: Membrane pore former]]
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[[Category: Pore]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:22:40 2008''
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Current revision

E.coli Hemolysin E (HlyE, ClyA, SheA)

PDB ID 1qoy

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