1od8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:36, 13 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1od8.png|left|200px]]
 
-
<!--
+
==Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-isofagomine lactam==
-
The line below this paragraph, containing "STRUCTURE_1od8", creates the "Structure Box" on the page.
+
<StructureSection load='1od8' size='340' side='right'caption='[[1od8]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1od8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XDL:XYLOSE-DERIVED+ISOFAGOMINE+LACTAM'>XDL</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
-
{{STRUCTURE_1od8| PDB=1od8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od8 OCA], [https://pdbe.org/1od8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od8 RCSB], [https://www.ebi.ac.uk/pdbsum/1od8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/XYNA_STRLI XYNA_STRLI] Contributes to hydrolyze hemicellulose, the major component of plant cell-walls. XLNA and XLNB seem to act sequentially on the substrate to yield xylobiose and xylose as carbon sources.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1od8 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.
-
===XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM===
+
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.,Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311<ref>PMID:12744311</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12744311}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1od8" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12744311 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12744311}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1OD8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD8 OCA].
+
-
 
+
-
==Reference==
+
-
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer., Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12744311 12744311]
+
-
[[Category: Endo-1,4-beta-xylanase]]
+
-
[[Category: Single protein]]
+
[[Category: Streptomyces lividans]]
[[Category: Streptomyces lividans]]
-
[[Category: Davies, G J.]]
+
[[Category: Davies GJ]]
-
[[Category: Gloster, T M.]]
+
[[Category: Gloster TM]]
-
[[Category: Roberts, S.]]
+
[[Category: Roberts S]]
-
[[Category: Glycoside hydrolase family 10]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Isofagomine lactam]]
+
-
[[Category: Lectin]]
+
-
[[Category: Transition state mimic]]
+
-
[[Category: Xylan degradation]]
+
-
[[Category: Xylanase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:30:01 2008''
+

Current revision

Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-isofagomine lactam

PDB ID 1od8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1od8"
Personal tools