1q40

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(New page: 200px<br /><applet load="1q40" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q40, resolution 1.95&Aring;" /> '''Crystal structure of...)
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[[Image:1q40.gif|left|200px]]<br /><applet load="1q40" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1q40, resolution 1.95&Aring;" />
 
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'''Crystal structure of the C. albicans Mtr2-Mex67 M domain complex'''<br />
 
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==Overview==
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==Crystal structure of the C. albicans Mtr2-Mex67 M domain complex==
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The formation of the Mtr2-Mex67 heterodimer is essential for yeast mRNA, export as it constitutes a key nuclear component for shuttling mRNA, between the nuclear and cytoplasm compartments through the nuclear pore, complex. We report the crystal structures of apo-Mtr2 from the human, pathogen Candida albicans and of its complex with the Mex67 NTF2-like, domain. Compared with other members of the NTF2 fold family, Mtr2 displays, novel structural features involved in the nuclear export of the large, ribosomal subunit and consistent with a dual functional role of Mtr2, during yeast nuclear export events. The structure of the Mtr2-Mex67, NTF2-like domain complex, which overall is similar to those of the human, and Saccharomyces cerevisiae homologs, unveils three putative Phe-Gly, repeat binding sites, of which one contributes to the heterodimer, interface. These structures exemplify an unrecognized adaptability of the, NTF2 building block in evolution, identify novel structural determinants, associated with key biological functions at the molecular surface of the, yeast Mtr2-Mex67 complex, and suggest that the yeast and human mRNA export, machineries may differ.
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<StructureSection load='1q40' size='340' side='right'caption='[[1q40]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q40 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q40 OCA], [https://pdbe.org/1q40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q40 RCSB], [https://www.ebi.ac.uk/pdbsum/1q40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q40 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTR2_CANAX MTR2_CANAX] Affects mRNA transport from the nucleus to the cytoplasm.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q4/1q40_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q40 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The formation of the Mtr2-Mex67 heterodimer is essential for yeast mRNA export as it constitutes a key nuclear component for shuttling mRNA between the nuclear and cytoplasm compartments through the nuclear pore complex. We report the crystal structures of apo-Mtr2 from the human pathogen Candida albicans and of its complex with the Mex67 NTF2-like domain. Compared with other members of the NTF2 fold family, Mtr2 displays novel structural features involved in the nuclear export of the large ribosomal subunit and consistent with a dual functional role of Mtr2 during yeast nuclear export events. The structure of the Mtr2-Mex67 NTF2-like domain complex, which overall is similar to those of the human and Saccharomyces cerevisiae homologs, unveils three putative Phe-Gly repeat binding sites, of which one contributes to the heterodimer interface. These structures exemplify an unrecognized adaptability of the NTF2 building block in evolution, identify novel structural determinants associated with key biological functions at the molecular surface of the yeast Mtr2-Mex67 complex, and suggest that the yeast and human mRNA export machineries may differ.
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==About this Structure==
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The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export.,Senay C, Ferrari P, Rocher C, Rieger KJ, Winter J, Platel D, Bourne Y J Biol Chem. 2003 Nov 28;278(48):48395-403. Epub 2003 Sep 22. PMID:14504280<ref>PMID:14504280</ref>
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1Q40 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Q40 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export., Senay C, Ferrari P, Rocher C, Rieger KJ, Winter J, Platel D, Bourne Y, J Biol Chem. 2003 Nov 28;278(48):48395-403. Epub 2003 Sep 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14504280 14504280]
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</div>
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<div class="pdbe-citations 1q40" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bourne, Y.]]
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[[Category: Bourne Y]]
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[[Category: Ferrari, P.]]
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[[Category: Ferrari P]]
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[[Category: Platel, D.]]
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[[Category: Platel D]]
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[[Category: Rieger, K.J.]]
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[[Category: Rieger KJ]]
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[[Category: Rocher, C.]]
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[[Category: Rocher C]]
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[[Category: Senay, C.]]
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[[Category: Senay C]]
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[[Category: Winter, J.]]
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[[Category: Winter J]]
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[[Category: GOL]]
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[[Category: ntf2-fold; nuclear export]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:22:05 2007''
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Current revision

Crystal structure of the C. albicans Mtr2-Mex67 M domain complex

PDB ID 1q40

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