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1mxt

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{{Seed}}
 
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[[Image:1mxt.png|left|200px]]
 
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==Atomic resolution structure of Cholesterol oxidase (Streptomyces sp. SA-COO)==
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The line below this paragraph, containing "STRUCTURE_1mxt", creates the "Structure Box" on the page.
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<StructureSection load='1mxt' size='340' side='right'caption='[[1mxt]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mxt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MXT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAE:FLAVIN-N7+PROTONATED-ADENINE+DINUCLEOTIDE'>FAE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1mxt| PDB=1mxt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxt OCA], [https://pdbe.org/1mxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mxt RCSB], [https://www.ebi.ac.uk/pdbsum/1mxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mxt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHOD_STRS0 CHOD_STRS0] Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mxt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mxt ConSurf].
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<div style="clear:both"></div>
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===Atomic resolution structure of Cholesterol oxidase (Streptomyces sp. SA-COO)===
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==See Also==
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*[[Cholesterol oxidase|Cholesterol oxidase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12595270}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12595270 is the PubMed ID number.
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[[Category: Streptomyces sp]]
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[[Category: Lario PI]]
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{{ABSTRACT_PUBMED_12595270}}
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[[Category: Vrielink A]]
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==About this Structure==
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1MXT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXT OCA].
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==Reference==
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Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity., Lario PI, Sampson N, Vrielink A, J Mol Biol. 2003 Mar 7;326(5):1635-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595270 12595270]
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Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment., Lyubimov AY, Lario PI, Moustafa I, Vrielink A, Nat Chem Biol. 2006 May;2(5):259-64. Epub 2006 Apr 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16604066 16604066]
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[[Category: Cholesterol oxidase]]
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[[Category: Single protein]]
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[[Category: Streptomyces sp.]]
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[[Category: Lario, P I.]]
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[[Category: Vrielink, A.]]
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[[Category: Atomic resolution]]
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[[Category: Flavoenzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Steroid metabolism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:03:54 2008''
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Current revision

Atomic resolution structure of Cholesterol oxidase (Streptomyces sp. SA-COO)

PDB ID 1mxt

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