2msp

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{{Seed}}
 
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[[Image:2msp.png|left|200px]]
 
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==MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5==
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The line below this paragraph, containing "STRUCTURE_2msp", creates the "Structure Box" on the page.
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<StructureSection load='2msp' size='340' side='right'caption='[[2msp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2msp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MSP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2msp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msp OCA], [https://pdbe.org/2msp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2msp RCSB], [https://www.ebi.ac.uk/pdbsum/2msp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2msp ProSAT]</span></td></tr>
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{{STRUCTURE_2msp| PDB=2msp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSP2_ASCSU MSP2_ASCSU] Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/2msp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2msp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cell locomotion in amoeboid nematode sperm is generated by the vectorial assembly and bundling of filaments of the major sperm protein (MSP). MSP filaments are constructed from two helical subfilaments and here we describe the structure of putative MSP subfilament helices determined by X-ray crystallography at 3.3 A resolution. In addition to establishing the interfaces involved in polymerization, this structural model shows that the MSP helices are constructed from dimers and have no overall polarity, suggesting that it is unlikely that molecular motors play a direct role in the generation of protrusive force in these amoeboid cells.
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===MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5===
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Structural basis for amoeboid motility in nematode sperm.,Bullock TL, McCoy AJ, Kent HM, Roberts TM, Stewart M Nat Struct Biol. 1998 Mar;5(3):184-9. PMID:9501910<ref>PMID:9501910</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9501910}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2msp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9501910 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9501910}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2MSP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSP OCA].
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==Reference==
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Structural basis for amoeboid motility in nematode sperm., Bullock TL, McCoy AJ, Kent HM, Roberts TM, Stewart M, Nat Struct Biol. 1998 Mar;5(3):184-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9501910 9501910]
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[[Category: Ascaris suum]]
[[Category: Ascaris suum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bullock, T L.]]
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[[Category: Bullock TL]]
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[[Category: Mccoy, A J.]]
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[[Category: Mccoy AJ]]
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[[Category: Stewart, M.]]
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[[Category: Stewart M]]
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[[Category: Cytoskeletal protein]]
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[[Category: Filamentous protein structure]]
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[[Category: Nematode sperm cell motility protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:10:53 2008''
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Current revision

MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5

PDB ID 2msp

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