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1nea

From Proteopedia

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{{Seed}}
 
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[[Image:1nea.png|left|200px]]
 
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==THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY==
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The line below this paragraph, containing "STRUCTURE_1nea", creates the "Structure Box" on the page.
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<StructureSection load='1nea' size='340' side='right'caption='[[1nea]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nea OCA], [https://pdbe.org/1nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nea RCSB], [https://www.ebi.ac.uk/pdbsum/1nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nea ProSAT]</span></td></tr>
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{{STRUCTURE_1nea| PDB=1nea | SCENE= }}
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</table>
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== Function ==
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===THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY===
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[https://www.uniprot.org/uniprot/3S11_NAJPA 3S11_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata AChR, Kd=0.07 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric receptor, Kd=3 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:9305882). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_1332755}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 1332755 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nea_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_1332755}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nea ConSurf].
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1NEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEA OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Three-dimensional solution structure of a curaremimetic toxin from Naja nigricollis venom: a proton NMR and molecular modeling study., Zinn-Justin S, Roumestand C, Gilquin B, Bontems F, Menez A, Toma F, Biochemistry. 1992 Nov 24;31(46):11335-47. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1332755 1332755]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Naja nigricollis]]
[[Category: Naja nigricollis]]
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[[Category: Single protein]]
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[[Category: Bontems F]]
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[[Category: Bontems, F.]]
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[[Category: Gilquin B]]
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[[Category: Gilquin, B.]]
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[[Category: Menez A]]
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[[Category: Menez, A.]]
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[[Category: Roumestand C]]
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[[Category: Roumestand, C.]]
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[[Category: Toma F]]
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[[Category: Toma, F.]]
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[[Category: Zinn-Justin S]]
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[[Category: Zinn-Justin, S.]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:12:19 2008''
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Current revision

THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY

PDB ID 1nea

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