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2bn5

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{{Seed}}
 
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[[Image:2bn5.png|left|200px]]
 
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==P-Element Somatic Inhibitor Protein Complex with U1-70k proline-rich peptide==
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The line below this paragraph, containing "STRUCTURE_2bn5", creates the "Structure Box" on the page.
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<StructureSection load='2bn5' size='340' side='right'caption='[[2bn5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bn5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BN5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bn5 OCA], [https://pdbe.org/2bn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bn5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bn5 ProSAT]</span></td></tr>
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{{STRUCTURE_2bn5| PDB=2bn5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7JPS0_DROSP Q7JPS0_DROSP]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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P-element transposition in Drosophila is regulated by tissue-specific alternative splicing of the P-element transposase pre-mRNA. In somatic cells, the P-element somatic inhibitor (PSI) protein binds to exon 3 of the pre-mRNA and recruits U1 small nuclear ribonucleoprotein (snRNP) to the F1 pseudo-splice site. This abrogates binding of U1 snRNP to the genuine 5' splice site, thereby preventing excision of the third intron. Two homologous short sequences, referred to as the A and B boxes, near the C terminus of PSI bind to U1-70k protein within U1 snRNP. We have now mapped the AB box-binding site of U1-70k to a short proline-rich sequence at the C terminus. Our NMR study shows that the B box forms an anti-parallel helical hairpin in which four highly conserved aromatic residues form a cluster on one face of the first helix. This hydrophobic cluster interacts extensively with the proline-rich region of the U1-70k protein.
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===P-ELEMENT SOMATIC INHIBITOR PROTEIN COMPLEX WITH U1-70K PROLINE-RICH PEPTIDE===
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Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase.,Ignjatovic T, Yang JC, Butler J, Neuhaus D, Nagai K J Mol Biol. 2005 Aug 5;351(1):52-65. PMID:15990112<ref>PMID:15990112</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2bn5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15990112 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15990112}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BN5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN5 OCA].
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==Reference==
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Structural basis of the interaction between P-element somatic inhibitor and U1-70k essential for the alternative splicing of P-element transposase., Ignjatovic T, Yang JC, Butler J, Neuhaus D, Nagai K, J Mol Biol. 2005 Aug 5;351(1):52-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15990112 15990112]
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Butler, P J.G.]]
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[[Category: Butler PJG]]
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[[Category: Ignjatovic, T.]]
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[[Category: Ignjatovic T]]
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[[Category: Nagai, K.]]
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[[Category: Nagai K]]
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[[Category: Neuhaus, D.]]
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[[Category: Neuhaus D]]
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[[Category: Yang, J C.]]
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[[Category: Yang J-C]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Nmr structure]]
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[[Category: Nuclear protein/complex]]
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[[Category: Proline-rich peptide]]
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[[Category: Protein-protein interaction]]
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[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:15:12 2008''
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Current revision

P-Element Somatic Inhibitor Protein Complex with U1-70k proline-rich peptide

PDB ID 2bn5

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