2hnh

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{{Seed}}
 
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[[Image:2hnh.png|left|200px]]
 
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==Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III==
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The line below this paragraph, containing "STRUCTURE_2hnh", creates the "Structure Box" on the page.
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<StructureSection load='2hnh' size='340' side='right'caption='[[2hnh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HNH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2hnh| PDB=2hnh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hnh OCA], [https://pdbe.org/2hnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hnh RCSB], [https://www.ebi.ac.uk/pdbsum/2hnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hnh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO3A_ECOLI DPO3A_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/2hnh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hnh ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16959568}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16959568 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16959568}}
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==About this Structure==
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2HNH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNH OCA].
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==Reference==
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Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III., Lamers MH, Georgescu RE, Lee SG, O'Donnell M, Kuriyan J, Cell. 2006 Sep 8;126(5):881-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16959568 16959568]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Donnell, M O.]]
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[[Category: Georgescu RE]]
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[[Category: Georgescu, R E.]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J.]]
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[[Category: Lee S]]
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[[Category: Lee, S.]]
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[[Category: Meindert MH]]
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[[Category: Meindert, M H.]]
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[[Category: O'Donnell M]]
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[[Category: Dna polymerase iii]]
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[[Category: Dna replication]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Php]]
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[[Category: Pol beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:21:36 2008''
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Current revision

Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III

PDB ID 2hnh

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