2fh4

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{{Seed}}
 
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[[Image:2fh4.png|left|200px]]
 
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==C-terminal half of gelsolin soaked in EGTA at pH 8==
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The line below this paragraph, containing "STRUCTURE_2fh4", creates the "Structure Box" on the page.
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<StructureSection load='2fh4' size='340' side='right'caption='[[2fh4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fh4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FH4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh4 OCA], [https://pdbe.org/2fh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fh4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fh4 ProSAT]</span></td></tr>
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{{STRUCTURE_2fh4| PDB=2fh4 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:[https://omim.org/entry/105120 105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.<ref>PMID:2157434</ref> <ref>PMID:2153578</ref> <ref>PMID:2176481</ref> <ref>PMID:1338910</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GELS_HUMAN GELS_HUMAN] Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fh4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fh4 ConSurf].
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<div style="clear:both"></div>
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===C-terminal half of gelsolin soaked in EGTA at pH 8===
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==See Also==
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*[[Gelsolin 3D structures|Gelsolin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16466744 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16466744}}
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==About this Structure==
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2FH4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH4 OCA].
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==Reference==
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Calcium ion exchange in crystalline gelsolin., Chumnarnsilpa S, Loonchanta A, Xue B, Choe H, Urosev D, Wang H, Lindberg U, Burtnick LD, Robinson RC, J Mol Biol. 2006 Mar 31;357(3):773-82. Epub 2006 Jan 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16466744 16466744]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burtnick, L D.]]
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[[Category: Burtnick LD]]
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[[Category: Choe, H.]]
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[[Category: Choe H]]
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[[Category: Chumnarnsilpa, S.]]
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[[Category: Chumnarnsilpa S]]
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[[Category: Loonchanta, A.]]
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[[Category: Loonchanta A]]
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[[Category: Robinson, R C.]]
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[[Category: Robinson RC]]
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[[Category: Urosev, D.]]
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[[Category: Urosev D]]
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[[Category: Wang, H.]]
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[[Category: Wang H]]
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[[Category: Xue, B.]]
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[[Category: Xue B]]
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[[Category: Egta]]
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[[Category: Gelsolin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:23:28 2008''
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Current revision

C-terminal half of gelsolin soaked in EGTA at pH 8

PDB ID 2fh4

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