3c2g

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{{Seed}}
 
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[[Image:3c2g.png|left|200px]]
 
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==Crystal complex of SYS-1/POP-1 at 2.5A resolution==
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The line below this paragraph, containing "STRUCTURE_3c2g", creates the "Structure Box" on the page.
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<StructureSection load='3c2g' size='340' side='right'caption='[[3c2g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C2G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3c2g| PDB=3c2g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c2g OCA], [https://pdbe.org/3c2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c2g RCSB], [https://www.ebi.ac.uk/pdbsum/3c2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c2g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTNH1_CAEEL CTNH1_CAEEL] Transcription coregulator (PubMed:26073017). Part of the Wnt signaling asymmetry pathway, probably acting downstream of putative frizzled ligand mom-2, Wnt/frizzled receptors lin-17 and mom-5, and dishevelled homolog dsh-2 (PubMed:15020416, PubMed:17296929, PubMed:17567664, PubMed:19386265, PubMed:26073017). Activates or represses target gene expression, depending on upstream Wnt signals and interactions with transcription factors, such as pop-1 (PubMed:26073017, PubMed:35660370). Required for the activation of Wnt-responsive genes in the E blastomere; thereby leading to a role in endoderm specification and gut development (PubMed:17296929, PubMed:17567664). Reciprocal distribution patterns of sys-1 and pop-1/TCF in the daughters of anterior-posterior cell divisions functions in specifying cell fate; a higher sys-1 to pop-1 ratio promotes the posterior cell fate, whereas a low sys-1 to pop-1 ratio promotes the anterior fate (PubMed:17296929, PubMed:17567664). Represses expression of homeobox ttx-3 in neuroblasts of the SIAD/SIBV lineage, perhaps acting by blocking its transcriptional activation by a complex consisting of ref-2 and pop-1 (PubMed:26073017). Required for early organization of the hermaphrodite, but not the male, gonad; involved in generation of regulatory cells, known as the distal tip cells (DTC), and in formation of the somatic gonadal primordium (PubMed:11161562, PubMed:15020416, PubMed:17296929, PubMed:35196020). Involved in regulating asymmetric divisions of the somatic gonadal precursor cells (SGP), Z1 and Z4 (PubMed:15020416).<ref>PMID:11161562</ref> <ref>PMID:15020416</ref> <ref>PMID:17296929</ref> <ref>PMID:17567664</ref> <ref>PMID:19386265</ref> <ref>PMID:26073017</ref> <ref>PMID:35196020</ref> <ref>PMID:35660370</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
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===Crystal complex of SYS-1/POP-1 at 2.5A resolution===
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The C. elegans SYS-1 protein is a bona fide beta-catenin.,Liu J, Phillips BT, Amaya MF, Kimble J, Xu W Dev Cell. 2008 May;14(5):751-61. PMID:18477457<ref>PMID:18477457</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3c2g" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18477457 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18477457}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3C2G is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2G OCA].
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==Reference==
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The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18477457 18477457]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Amaya, M F.]]
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[[Category: Amaya MF]]
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[[Category: Kimble, J.]]
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[[Category: Kimble J]]
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[[Category: Liu, J.]]
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[[Category: Liu J]]
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[[Category: Phillips, B T.]]
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[[Category: Phillips BT]]
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[[Category: Xu, W.]]
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[[Category: Xu W]]
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[[Category: Beta-catenin]]
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[[Category: Caenorhabditis elegan]]
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[[Category: Cell adhesion/transcription complex]]
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[[Category: Crystal structure]]
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[[Category: Developmental protein]]
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[[Category: Dna-binding]]
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[[Category: Nucleus]]
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[[Category: Phylogeny]]
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[[Category: Pop-1]]
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[[Category: Sys-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:32:33 2008''
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Current revision

Crystal complex of SYS-1/POP-1 at 2.5A resolution

PDB ID 3c2g

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