2pp4

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{{Seed}}
 
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[[Image:2pp4.png|left|200px]]
 
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==Solution Structure of ETO-TAFH refined in explicit solvent==
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The line below this paragraph, containing "STRUCTURE_2pp4", creates the "Structure Box" on the page.
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<StructureSection load='2pp4' size='340' side='right'caption='[[2pp4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2pp4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PP4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pp4 OCA], [https://pdbe.org/2pp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pp4 RCSB], [https://www.ebi.ac.uk/pdbsum/2pp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pp4 ProSAT]</span></td></tr>
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{{STRUCTURE_2pp4| PDB=2pp4 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
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== Function ==
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[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2pp4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pp4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.
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===Solution Structure of ETO-TAFH refined in explicit solvent===
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A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription.,Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:17572682<ref>PMID:17572682</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17572682}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2pp4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17572682 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17572682}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2PP4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PP4 OCA].
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==Reference==
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A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription., Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH, Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17572682 17572682]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Biris, N.]]
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[[Category: Biris N]]
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[[Category: Cho, S.]]
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[[Category: Cho S]]
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[[Category: Kobayashi, N.]]
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[[Category: Kobayashi N]]
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[[Category: Lausen, J.]]
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[[Category: Lausen J]]
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[[Category: Liu, S.]]
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[[Category: Liu S]]
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[[Category: Wei, Y.]]
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[[Category: Wei Y]]
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[[Category: Werner, M H.]]
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[[Category: Werner MH]]
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[[Category: Woodrell, C.]]
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[[Category: Woodrell C]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: 4-helix bundle]]
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[[Category: Leukemia]]
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[[Category: Transcriptional cofactor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:33:03 2008''
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Current revision

Solution Structure of ETO-TAFH refined in explicit solvent

PDB ID 2pp4

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