2hb4

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{{Seed}}
 
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[[Image:2hb4.png|left|200px]]
 
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==Structure of HIV Protease NL4-3 in an Unliganded State==
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The line below this paragraph, containing "STRUCTURE_2hb4", creates the "Structure Box" on the page.
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<StructureSection load='2hb4' size='340' side='right'caption='[[2hb4]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HB4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGR:R-1,2-PROPANEDIOL'>PGR</scene></td></tr>
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{{STRUCTURE_2hb4| PDB=2hb4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hb4 OCA], [https://pdbe.org/2hb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hb4 ProSAT]</span></td></tr>
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</table>
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===Structure of HIV Protease NL4-3 in an Unliganded State===
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== Function ==
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[https://www.uniprot.org/uniprot/Q903N5_9HIV1 Q903N5_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17642513 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/2hb4_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17642513}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2HB4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hb4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Conformational flexibility in the flap domains of ligand-free HIV protease., Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee DE, Stout CD, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):866-75. Epub 2007, Jul 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17642513 17642513]
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</StructureSection>
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Elder, J H.]]
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[[Category: Elder JH]]
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[[Category: Heaslet, H.]]
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[[Category: Heaslet H]]
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[[Category: Stout, C D.]]
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[[Category: Stout CD]]
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[[Category: Tam, K.]]
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[[Category: Tam K]]
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[[Category: Aspartyl]]
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[[Category: Hiv]]
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[[Category: Protease]]
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[[Category: Retrovirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:34:57 2008''
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Current revision

Structure of HIV Protease NL4-3 in an Unliganded State

PDB ID 2hb4

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