28sp

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{{Seed}}
 
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[[Image:28sp.png|left|200px]]
 
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==NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA==
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The line below this paragraph, containing "STRUCTURE_28sp", creates the "Structure Box" on the page.
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<StructureSection load='28sp' size='340' side='right'caption='[[28sp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[28sp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28SP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=28SP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=28sp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=28sp OCA], [https://pdbe.org/28sp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=28sp RCSB], [https://www.ebi.ac.uk/pdbsum/28sp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=28sp ProSAT]</span></td></tr>
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{{STRUCTURE_28sp| PDB=28sp | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The signal recognition particle (SRP) directs translating ribosomes to the protein translocation apparatus of endoplasmic reticulum (ER) membrane or the bacterial plasma membrane. The SRP is universally conserved, and in prokaryotes consists of two essential subunits, SRP RNA and SRP54, the latter of which binds to signal sequences on the nascent protein chains. Here we describe the solution NMR structure of a 28-mer RNA composing the most conserved part of SRP RNA to which SRP54 binds. Central to this function is a six-nucleotide internal loop that assumes a novel Mg2+-dependent structure with unusual cross-strand interactions; besides a cross-strand A/A stack, two guanines form hydrogen bonds with opposite-strand phosphates. The structure completely explains the phylogenetic conservation of the loop bases, underlining its importance for SRP54 binding and SRP function.
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===NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA===
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Structure of the most conserved internal loop in SRP RNA.,Schmitz U, James TL, Lukavsky P, Walter P Nat Struct Biol. 1999 Jul;6(7):634-8. PMID:10404218<ref>PMID:10404218</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 28sp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10404218 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10404218}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=28SP OCA].
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[[Category: Large Structures]]
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[[Category: James TL]]
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==Reference==
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[[Category: Lukavsky P]]
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Structure of the most conserved internal loop in SRP RNA., Schmitz U, James TL, Lukavsky P, Walter P, Nat Struct Biol. 1999 Jul;6(7):634-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10404218 10404218]
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[[Category: Schmitz U]]
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[[Category: James, T L.]]
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[[Category: Walter P]]
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[[Category: Lukavsky, P.]]
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[[Category: Schmitz, U.]]
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[[Category: Walter, P.]]
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[[Category: 4 5s rna]]
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[[Category: Complete relaxation matrix analysis]]
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[[Category: Nmr of rna]]
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[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:50:49 2008''
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Current revision

NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA

PDB ID 28sp

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