2osn

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{{Seed}}
 
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[[Image:2osn.png|left|200px]]
 
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==An alternate description of a crystal structure of phospholipase A2 from Bungarus caeruleus==
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The line below this paragraph, containing "STRUCTURE_2osn", creates the "Structure Box" on the page.
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<StructureSection load='2osn' size='340' side='right'caption='[[2osn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2osn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_caeruleus Bungarus caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2osn| PDB=2osn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osn OCA], [https://pdbe.org/2osn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osn RCSB], [https://www.ebi.ac.uk/pdbsum/2osn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2B3_BUNCE PA2B3_BUNCE] Snake venom phospholipase A2 (PLA2) that shows anticoagulant and neurotoxic activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2osn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Reinterpretations of the space-group symmetry are reported for two crystal structures of phospholipase A(2) isoforms (PDB codes 1u4j and 1g2x). The two structures reported in space groups R3 and C2 are isomorphous with a third isoform with space group R32 (PDB code 1fe5). The original structure reports were interpreted in terms of different oligomeric forms of the isoforms, but these conclusions are not supported by the isomorphous structures.
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===An alternate description of a crystal structure of phospholipase A2 from Bungarus caeruleus===
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An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus.,Le Trong I, Stenkamp RE Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):548-9. Epub 2007, Mar 16. PMID:17372360<ref>PMID:17372360</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2osn" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17372360}}, adds the Publication Abstract to the page
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17372360 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17372360}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2OSN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_caeruleus Bungarus caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSN OCA].
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==Reference==
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An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus., Le Trong I, Stenkamp RE, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):548-9. Epub 2007, Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17372360 17372360]
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Sequence-induced trimerization of phospholipase A2: structure of a trimeric isoform of PLA2 from common krait (Bungarus caeruleus) at 2.5 A resolution., Singh G, Gourinath S, Saravanan K, Sharma S, Bhanumathi S, Betzel Ch, Srinivasan A, Singh TP, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt, 1):8-13. Epub 2004 Oct 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16508078 16508078]
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[[Category: Bungarus caeruleus]]
[[Category: Bungarus caeruleus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Stenkamp, R E.]]
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[[Category: Le Trong I]]
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[[Category: Trong, I Le.]]
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[[Category: Stenkamp RE]]
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[[Category: Krait venom]]
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[[Category: Phospholipase]]
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[[Category: Structure reinterpretation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:00:21 2008''
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Current revision

An alternate description of a crystal structure of phospholipase A2 from Bungarus caeruleus

PDB ID 2osn

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