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1qa6

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(New page: 200px<br /><applet load="1qa6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qa6, resolution 2.800&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1qa6.gif|left|200px]]<br /><applet load="1qa6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qa6, resolution 2.800&Aring;" />
 
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'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX==
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The structure of a highly conserved complex between a 58-nucleotide domain, of large subunit ribosomal RNA and the RNA-binding domain of ribosomal, protein L11 has been solved at 2.8 angstrom resolution. It reveals a, precisely folded RNA structure that is stabilized by extensive tertiary, contacts and contains an unusually large core of stacked bases. A bulge, loop base from one hairpin of the RNA is intercalated into the distorted, major groove of another helix; the protein locks this tertiary interaction, into place by binding to the intercalated base from the minor groove side., This direct interaction with a key ribosomal RNA tertiary interaction, suggests that part of the role of L11 is to stabilize an unusual RNA fold, within the ribosome.
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<StructureSection load='1qa6' size='340' side='right'caption='[[1qa6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qa6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QA6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa6 OCA], [https://pdbe.org/1qa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qa6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qa6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL11_GEOSE RL11_GEOSE] Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qa/1qa6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qa6 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1QA6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with MG and OS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QA6 OCA].
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*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10325228 10325228]
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[[Category: Escherichia coli]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Conn, G.L.]]
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[[Category: Conn GL]]
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[[Category: Draper, D.E.]]
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[[Category: Draper DE]]
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[[Category: Gittis, A.G.]]
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[[Category: Gittis AG]]
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[[Category: Lattman, E.E.]]
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[[Category: Lattman EE]]
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[[Category: MG]]
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[[Category: OS]]
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[[Category: antibiotic binding]]
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[[Category: e rna-protein interaction]]
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[[Category: minor groove binding]]
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[[Category: ribosomal rna]]
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[[Category: tertiary structur]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:31:10 2007''
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Current revision

CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX

PDB ID 1qa6

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