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2ont

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{{Seed}}
 
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[[Image:2ont.png|left|200px]]
 
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==A swapped dimer of the HIV-1 capsid C-terminal domain==
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The line below this paragraph, containing "STRUCTURE_2ont", creates the "Structure Box" on the page.
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<StructureSection load='2ont' size='340' side='right'caption='[[2ont]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ont]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ONT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ont FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ont OCA], [https://pdbe.org/2ont PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ont RCSB], [https://www.ebi.ac.uk/pdbsum/2ont PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ont ProSAT]</span></td></tr>
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{{STRUCTURE_2ont| PDB=2ont | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9IVQ4_9HIV1 Q9IVQ4_9HIV1]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Assembly of the HIV and other retroviruses is primarily driven by the oligomerization of the Gag polyprotein, the major viral structural protein capable of forming virus-like particles even in the absence of all other virally encoded components. Several critical determinants of Gag oligomerization are located in the C-terminal domain of the capsid protein (CA-CTD), which encompasses the most conserved segment in the highly variable Gag protein called the major homology region (MHR). The CA-CTD is thought to function as a dimerization module, although the existing model of CA-CTD dimerization does not readily explain why the conserved residues of the MHR are essential for retroviral assembly. Here we describe an x-ray structure of a distinct domain-swapped variant of the HIV-1 CA-CTD dimer stabilized by a single amino acid deletion. In the domain-swapped structure, the MHR-containing segment forms a major part of the dimerization interface, providing a structural mechanism for the enigmatic function of the MHR in HIV assembly. Our observations suggest that swapping of the MHR segments of adjacent Gag molecules may be a critical intermediate in retroviral assembly.
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===A swapped dimer of the HIV-1 capsid C-terminal domain===
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Domain-swapped dimerization of the HIV-1 capsid C-terminal domain.,Ivanov D, Tsodikov OV, Kasanov J, Ellenberger T, Wagner G, Collins T Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4353-8. Epub 2007 Mar 5. PMID:17360528<ref>PMID:17360528</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ont" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17360528}}, adds the Publication Abstract to the page
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17360528 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17360528}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2ONT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONT OCA].
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[[Category: Collins T]]
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[[Category: Ellenberger T]]
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==Reference==
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[[Category: Ivanov D]]
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Domain-swapped dimerization of the HIV-1 capsid C-terminal domain., Ivanov D, Tsodikov OV, Kasanov J, Ellenberger T, Wagner G, Collins T, Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4353-8. Epub 2007 Mar 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360528 17360528]
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[[Category: Kasanov J]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Tsodikov OV]]
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[[Category: Single protein]]
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[[Category: Wagner G]]
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[[Category: Collins, T.]]
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[[Category: Ellenberger, T.]]
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[[Category: Ivanov, D.]]
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[[Category: Kasanov, J.]]
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[[Category: Tsodikov, O V.]]
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[[Category: Wagner, G.]]
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[[Category: Capsid]]
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[[Category: Domain swap]]
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[[Category: Gag]]
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[[Category: Hiv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:26:42 2008''
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Current revision

A swapped dimer of the HIV-1 capsid C-terminal domain

PDB ID 2ont

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