2nrn

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{{Seed}}
 
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[[Image:2nrn.png|left|200px]]
 
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==Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant==
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The line below this paragraph, containing "STRUCTURE_2nrn", creates the "Structure Box" on the page.
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<StructureSection load='2nrn' size='340' side='right'caption='[[2nrn]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nrn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NRN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2nrn| PDB=2nrn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nrn OCA], [https://pdbe.org/2nrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nrn RCSB], [https://www.ebi.ac.uk/pdbsum/2nrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nrn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hydrophobic core of the GCN4 leucine-zipper dimerization domain is formed by a parallel helical association between nonpolar side chains at the a and d positions of the heptad repeat. Here we report a self-assembling coiled-coil array formed by the GCN4-pAe peptide that differs from the wild-type GCN4 leucine zipper by alanine substitutions at three charged e positions. GCN4-pAe is incompletely folded in normal solution conditions yet self-assembles into an antiparallel tetraplex in crystals by formation of unanticipated hydrophobic seams linking the last two heptads of two parallel double-stranded coiled coils. The GCN4-pAe tetramers in the lattice associate laterally through the identical interactions to those in the intramolecular dimer-dimer interface. The van der Waals packing interaction in the solid state controls extended supramolecular assembly of the protein, providing an unusual atomic scale view of a mesostructure.
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===Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant===
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Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant.,Deng Y, Zheng Q, Liu J, Cheng CS, Kallenbach NR, Lu M Protein Sci. 2007 Feb;16(2):323-8. Epub 2006 Dec 22. PMID:17189475<ref>PMID:17189475</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2nrn" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17189475}}, adds the Publication Abstract to the page
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*[[Gcn4 3D Structures|Gcn4 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17189475 is the PubMed ID number.
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*[[Gnc4 3D Structures|Gnc4 3D Structures]]
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== References ==
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{{ABSTRACT_PUBMED_17189475}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2NRN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NRN OCA].
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[[Category: Large Structures]]
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==Reference==
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Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant., Deng Y, Zheng Q, Liu J, Cheng CS, Kallenbach NR, Lu M, Protein Sci. 2007 Feb;16(2):323-8. Epub 2006 Dec 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17189475 17189475]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Liu J]]
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[[Category: Liu, J.]]
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[[Category: Lu M]]
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[[Category: Lu, M.]]
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[[Category: Coiled coil]]
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[[Category: Protein design]]
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[[Category: Protein structure]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:26:36 2008''
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Current revision

Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant

PDB ID 2nrn

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