2f08

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{{Seed}}
 
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[[Image:2f08.png|left|200px]]
 
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==Crystal structure of a major house dust mite allergen, Derf 2==
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The line below this paragraph, containing "STRUCTURE_2f08", creates the "Structure Box" on the page.
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<StructureSection load='2f08' size='340' side='right'caption='[[2f08]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f08]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/American_house_dust_mite American house dust mite]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F08 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f08 OCA], [https://pdbe.org/2f08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f08 RCSB], [https://www.ebi.ac.uk/pdbsum/2f08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f08 ProSAT]</span></td></tr>
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{{STRUCTURE_2f08| PDB=2f08 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f08_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f08 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pyroglyphid house dust mites are a major source of allergens in house dust. Mite allergens sensitize and induce asthma, rhinitis, and eczema in a large portion of patients with allergic diseases. Here, the crystal structure of a major mite allergen, Derf 2, derived from Dermatophagoides farinae was solved by single isomorphous replacement method with anomalous scattering (SIRAS) at 2.1A resolution. The present study also demonstrated that the conformation of the allergen was critical in the determination of Th1/Th2 shift based on physicochemical and immunological analyses. This indicates that rigidly folded and singly dispersed structure is essentially required for the generation of Th2 type cells by the allergen, while conformational variant protein leads to Th1 skewing, irrespective of the same amino acid sequence. This structure/function relationship may allow us to develop a novel strategy for hyposensitization therapy in patients with allergic diseases triggered by house dust mite allergens.
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===Crystal structure of a major house dust mite allergen, Derf 2===
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Crystal structure and some properties of a major house dust mite allergen, Derf 2.,Suzuki M, Tanaka Y, Korematsu S, Mikami B, Minato N Biochem Biophys Res Commun. 2006 Jan 13;339(2):679-86. Epub 2005 Nov 21. PMID:16313885<ref>PMID:16313885</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16313885}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2f08" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16313885 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16313885}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: American house dust mite]]
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2F08 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F08 OCA].
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[[Category: Large Structures]]
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[[Category: Korematsu, S]]
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==Reference==
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[[Category: Mikami, B]]
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Crystal structure and some properties of a major house dust mite allergen, Derf 2., Suzuki M, Tanaka Y, Korematsu S, Mikami B, Minato N, Biochem Biophys Res Commun. 2006 Jan 13;339(2):679-86. Epub 2005 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16313885 16313885]
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[[Category: Minato, N]]
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[[Category: Dermatophagoides farinae]]
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[[Category: Suzuki, M]]
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[[Category: Single protein]]
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[[Category: Tanaka, Y]]
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[[Category: Korematsu, S.]]
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[[Category: Immune system]]
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[[Category: Mikami, B.]]
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[[Category: Minato, N.]]
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[[Category: Suzuki, M.]]
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[[Category: Tanaka, Y.]]
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:33:10 2008''
 

Current revision

Crystal structure of a major house dust mite allergen, Derf 2

PDB ID 2f08

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