1qf3

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(New page: 200px<br /><applet load="1qf3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qf3, resolution 2.80&Aring;" /> '''PEANUT LECTIN COMPLE...)
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[[Image:1qf3.jpg|left|200px]]<br /><applet load="1qf3" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qf3, resolution 2.80&Aring;" />
 
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'''PEANUT LECTIN COMPLEXED WITH METHYL-BETA-GALACTOSE'''<br />
 
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==Overview==
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==PEANUT LECTIN COMPLEXED WITH METHYL-BETA-GALACTOSE==
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The crystal structures of complexes of peanut lectin with, methyl-beta-galactose and N-acetyllactosamine have been determined at 2.8, and 2.7 A, respectively. These, and the complexes involving lactose and, the T-antigenic disaccharide reported previously, permit a detailed, characterization of peanut-lectin-carbohydrate association and the role of, water molecules therein. The water molecules in the combining site are, substantially conserved in the four complexes. The role of interacting, sugar hydroxyl groups, when absent, are often mimicked by ordered water, molecules not only at the primary combining site, but also at the site of, the second sugar ring. The similarity of peanut-lectin-sugar interactions, with those in other galactose/N-acetylgalactosamine-specific lectins also, extend to a substantial degree to water bridges. The comparative study, provides a structural explanation for the exclusive specificity of peanut, lectin for galactose at the monosaccharide level, compared with that of, the other lectins for galactose as well as N-acetylgalactosamine. The, complexes also provide a qualitative structural rationale for differences, in the strengths of binding of peanut lectin to different sugars.
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<StructureSection load='1qf3' size='340' side='right'caption='[[1qf3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qf3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QF3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MBG:METHYL-BETA-GALACTOSE'>MBG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf3 OCA], [https://pdbe.org/1qf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qf3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qf3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LECG_ARAHY LECG_ARAHY] D-galactose specific lectin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/1qf3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qf3 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1QF3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea] with MBG, CA and MN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QF3 OCA].
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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*[[Galactose-binding lectin|Galactose-binding lectin]]
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==Reference==
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__TOC__
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Structures of the complexes of peanut lectin with methyl-beta-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNAc-specific legume lectins., Ravishankar R, Suguna K, Surolia A, Vijayan M, Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1375-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10417405 10417405]
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</StructureSection>
[[Category: Arachis hypogaea]]
[[Category: Arachis hypogaea]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ravishankar, R.]]
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[[Category: Ravishankar R]]
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[[Category: Suguna, K.]]
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[[Category: Suguna K]]
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[[Category: Surolia, A.]]
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[[Category: Surolia A]]
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[[Category: Vijayan, M.]]
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[[Category: Vijayan M]]
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[[Category: CA]]
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[[Category: MBG]]
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[[Category: MN]]
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[[Category: carbohydrate specificity]]
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[[Category: lectin]]
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[[Category: legume lectin]]
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[[Category: methyl-beta- galactose]]
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[[Category: water bridges]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:37:32 2007''
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Current revision

PEANUT LECTIN COMPLEXED WITH METHYL-BETA-GALACTOSE

PDB ID 1qf3

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