1np6

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{{Seed}}
 
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[[Image:1np6.png|left|200px]]
 
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==Crystal structure of Escherichia coli MobB==
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The line below this paragraph, containing "STRUCTURE_1np6", creates the "Structure Box" on the page.
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<StructureSection load='1np6' size='340' side='right'caption='[[1np6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1np6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NP6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1np6| PDB=1np6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1np6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1np6 OCA], [https://pdbe.org/1np6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1np6 RCSB], [https://www.ebi.ac.uk/pdbsum/1np6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1np6 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Escherichia coli MobB===
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== Function ==
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[https://www.uniprot.org/uniprot/MOBB_ECOLI MOBB_ECOLI] GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP.<ref>PMID:9219527</ref> <ref>PMID:10978348</ref> <ref>PMID:12682065</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12682065 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1np6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12682065}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1NP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NP6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1np6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Insight into the role of Escherichia coli MobB in molybdenum cofactor biosynthesis based on the high resolution crystal structure., McLuskey K, Harrison JA, Schuttelkopf AW, Boxer DH, Hunter WN, J Biol Chem. 2003 Jun 27;278(26):23706-13. Epub 2003 Apr 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12682065 12682065]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boxer, D H.]]
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[[Category: Boxer DH]]
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[[Category: Harrison, J A.]]
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[[Category: Harrison JA]]
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[[Category: Hunter, W N.]]
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[[Category: Hunter WN]]
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[[Category: McLuskey, K.]]
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[[Category: McLuskey K]]
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[[Category: Schuttelkopf, A W.]]
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[[Category: Schuttelkopf AW]]
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[[Category: Elongated beta-sheet]]
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[[Category: Mixed alpha-beta fold]]
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[[Category: P-loop structural motif]]
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[[Category: Walker a motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:02:59 2008''
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Current revision

Crystal structure of Escherichia coli MobB

PDB ID 1np6

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