2e3q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:48, 13 March 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2e3q.png|left|200px]]
 
-
<!--
+
==Crystal structure of CERT START domain in complex with C18-ceramide (P212121)==
-
The line below this paragraph, containing "STRUCTURE_2e3q", creates the "Structure Box" on the page.
+
<StructureSection load='2e3q' size='340' side='right'caption='[[2e3q]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2e3q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3Q FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=18C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE'>18C</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-
{{STRUCTURE_2e3q| PDB=2e3q | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3q OCA], [https://pdbe.org/2e3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3q RCSB], [https://www.ebi.ac.uk/pdbsum/2e3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3q ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal structure of CERT START domain in complex with C18-ceramide (P212121)===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
-
 
+
== Function ==
-
<!--
+
[https://www.uniprot.org/uniprot/CERT_HUMAN CERT_HUMAN] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18184806}}, adds the Publication Abstract to the page
+
== Evolutionary Conservation ==
-
(as it appears on PubMed at http://www.pubmed.gov), where 18184806 is the PubMed ID number.
+
[[Image:Consurf_key_small.gif|200px|right]]
-
-->
+
Check<jmol>
-
{{ABSTRACT_PUBMED_18184806}}
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/2e3q_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
2E3Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3Q OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==Reference==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e3q ConSurf].
-
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide., Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R, Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18184806 18184806]
+
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hanada, K.]]
+
[[Category: Hanada K]]
-
[[Category: Kato, R.]]
+
[[Category: Kato R]]
-
[[Category: Kudo, N.]]
+
[[Category: Kudo N]]
-
[[Category: Kumagai, K.]]
+
[[Category: Kumagai K]]
-
[[Category: Nishijima, M.]]
+
[[Category: Nishijima M]]
-
[[Category: Wakatsuki, S.]]
+
[[Category: Wakatsuki S]]
-
[[Category: Ceramide transfer]]
+
-
[[Category: Cert]]
+
-
[[Category: Lipid transfer protein]]
+
-
[[Category: Lipid transport]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:17:05 2008''
+

Current revision

Crystal structure of CERT START domain in complex with C18-ceramide (P212121)

PDB ID 2e3q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e3q"
Personal tools