1r8p

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{{Seed}}
 
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[[Image:1r8p.png|left|200px]]
 
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==HPV-16 E2C solution structure==
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The line below this paragraph, containing "STRUCTURE_1r8p", creates the "Structure Box" on the page.
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<StructureSection load='1r8p' size='340' side='right'caption='[[1r8p]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8p OCA], [https://pdbe.org/1r8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8p RCSB], [https://www.ebi.ac.uk/pdbsum/1r8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8p ProSAT]</span></td></tr>
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{{STRUCTURE_1r8p| PDB=1r8p | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VE2_HPV16 VE2_HPV16] Plays an accessory role in initiation of DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.<ref>PMID:3033289</ref> <ref>PMID:1326651</ref> <ref>PMID:15681049</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8p ConSurf].
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<div style="clear:both"></div>
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===HPV-16 E2C solution structure===
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
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== References ==
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==About this Structure==
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<references/>
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1R8P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8P OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric beta-barrel fold., Nadra AD, Eliseo T, Mok YK, Almeida CL, Bycroft M, Paci M, de Prat-Gay G, Cicero DO, J Biomol NMR. 2004 Oct;30(2):211-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15702528 15702528]
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[[Category: Human papillomavirus type 16]]
[[Category: Human papillomavirus type 16]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cicero, D O.]]
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[[Category: Cicero DO]]
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[[Category: Eliseo, T.]]
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[[Category: Eliseo T]]
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[[Category: Nadra, A D.]]
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[[Category: Nadra AD]]
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[[Category: Dimeric beta-barrel]]
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[[Category: Dna binding protein]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:21:27 2008''
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Current revision

HPV-16 E2C solution structure

PDB ID 1r8p

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