1vyn

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{{Seed}}
 
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[[Image:1vyn.png|left|200px]]
 
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==STRUCTURE AND NUCLEIC ACID BINDING OF THE DROSOPHILA ARGONAUTE2 PAZ DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1vyn", creates the "Structure Box" on the page.
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<StructureSection load='1vyn' size='340' side='right'caption='[[1vyn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1upo 1upo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VYN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyn OCA], [https://pdbe.org/1vyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vyn RCSB], [https://www.ebi.ac.uk/pdbsum/1vyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vyn ProSAT]</span></td></tr>
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{{STRUCTURE_1vyn| PDB=1vyn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/1vyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vyn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RNA interference is a conserved mechanism that regulates gene expression in response to the presence of double-stranded (ds)RNAs. The RNase III-like enzyme Dicer first cleaves dsRNA into 21-23-nucleotide small interfering RNAs (siRNAs). In the effector step, the multimeric RNA-induced silencing complex (RISC) identifies messenger RNAs homologous to the siRNAs and promotes their degradation. The Argonaute 2 protein (Ago2) is a critical component of RISC. Both Argonaute and Dicer family proteins contain a common PAZ domain whose function is unknown. Here we present the three-dimensional nuclear magnetic resonance structure of the Drosophila melanogaster Ago2 PAZ domain. This domain adopts a nucleic-acid-binding fold that is stabilized by conserved hydrophobic residues. The nucleic-acid-binding patch is located in a cleft between the surface of a central beta-barrel and a conserved module comprising strands beta3, beta4 and helix alpha3. Because critical structural residues and the binding surface are conserved, we suggest that PAZ domains in all members of the Argonaute and Dicer families adopt a similar fold with nucleic-acid binding function, and that this plays an important part in gene silencing.
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===STRUCTURE AND NUCLEIC ACID BINDING OF THE DROSOPHILA ARGONAUTE2 PAZ DOMAIN===
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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain.,Lingel A, Simon B, Izaurralde E, Sattler M Nature. 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PMID:14615801<ref>PMID:14615801</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1vyn" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14615801}}, adds the Publication Abstract to the page
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*[[Argonaute 3D structures|Argonaute 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14615801 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14615801}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1VYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1upo 1upo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYN OCA].
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==Reference==
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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain., Lingel A, Simon B, Izaurralde E, Sattler M, Nature. 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14615801 14615801]
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Izaurralde, E.]]
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[[Category: Izaurralde E]]
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[[Category: Lingel, A.]]
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[[Category: Lingel A]]
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[[Category: Sattler, M.]]
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[[Category: Sattler M]]
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[[Category: Simon, B.]]
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[[Category: Simon B]]
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[[Category: Nucleic acid binding]]
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[[Category: Rna interference]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:22:54 2008''
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Current revision

STRUCTURE AND NUCLEIC ACID BINDING OF THE DROSOPHILA ARGONAUTE2 PAZ DOMAIN

PDB ID 1vyn

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