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1phk

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{{Seed}}
 
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[[Image:1phk.png|left|200px]]
 
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==TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT==
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The line below this paragraph, containing "STRUCTURE_1phk", creates the "Structure Box" on the page.
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<StructureSection load='1phk' size='340' side='right'caption='[[1phk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1phk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PHK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_1phk| PDB=1phk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1phk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1phk OCA], [https://pdbe.org/1phk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1phk RCSB], [https://www.ebi.ac.uk/pdbsum/1phk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1phk ProSAT]</span></td></tr>
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</table>
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===TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT===
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== Function ==
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[https://www.uniprot.org/uniprot/PHKG1_RABIT PHKG1_RABIT] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.<ref>PMID:8454596</ref> <ref>PMID:8999860</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_7663944}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 7663944 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/1phk_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_7663944}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1PHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1phk ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product., Owen DJ, Noble ME, Garman EF, Papageorgiou AC, Johnson LN, Structure. 1995 May 15;3(5):467-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7663944 7663944]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Phosphorylase kinase]]
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[[Category: Garman EF]]
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[[Category: Single protein]]
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[[Category: Johnson LN]]
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[[Category: Garman, E F.]]
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[[Category: Noble MEM]]
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[[Category: Johnson, L N.]]
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[[Category: Owen DJ]]
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[[Category: Noble, M E.M.]]
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[[Category: Papageorgiou AC]]
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[[Category: Owen, D J.]]
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[[Category: Papageorgiou, A C.]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Glycogen metabolism]]
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[[Category: Kinase]]
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[[Category: Serine/threonine-protein]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:24:55 2008''
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Current revision

TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT

PDB ID 1phk

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