1o9m

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{{Seed}}
 
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[[Image:1o9m.png|left|200px]]
 
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==The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.==
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The line below this paragraph, containing "STRUCTURE_1o9m", creates the "Structure Box" on the page.
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<StructureSection load='1o9m' size='340' side='right'caption='[[1o9m]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O9M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42B:4-AMINO-2-HYDROXYBUTANOIC+ACID'>42B</scene>, <scene name='pdbligand=BDG:O-2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSE'>BDG</scene>, <scene name='pdbligand=P24:1-(AMINOETHYL)AMINO-4-AMINOBUTANE'>P24</scene>, <scene name='pdbligand=PA2:PAROMOMYCIN+(RING+2)'>PA2</scene></td></tr>
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{{STRUCTURE_1o9m| PDB=1o9m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9m OCA], [https://pdbe.org/1o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o9m RCSB], [https://www.ebi.ac.uk/pdbsum/1o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o9m ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.
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===THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.===
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The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.,Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685<ref>PMID:12643685</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1o9m" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12643685 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12643685}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli]]
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1O9M is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9M OCA].
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[[Category: Large Structures]]
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[[Category: Murray JB]]
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==Reference==
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[[Category: Russell R]]
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The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12643685 12643685]
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[[Category: Single protein]]
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[[Category: Murray, J B.]]
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[[Category: Russell, R.]]
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[[Category: A-site]]
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[[Category: Rna-antibiotic interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:32:33 2008''
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Current revision

The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.

PDB ID 1o9m

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