2bn8

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{{Seed}}
 
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[[Image:2bn8.png|left|200px]]
 
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==Solution Structure and interactions of the E .coli Cell Division Activator Protein CedA==
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The line below this paragraph, containing "STRUCTURE_2bn8", creates the "Structure Box" on the page.
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<StructureSection load='2bn8' size='340' side='right'caption='[[2bn8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BN8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bn8 OCA], [https://pdbe.org/2bn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bn8 ProSAT]</span></td></tr>
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{{STRUCTURE_2bn8| PDB=2bn8 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CEDA_ECOLI CEDA_ECOLI] Activates the cell division inhibited by chromosomal DNA over-replication.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CedA is a protein that is postulated to be involved in the regulation of cell division in Escherichia coli and related organisms; however, little biological data about its possible mode of action are available. Here we present a three-dimensional structure of this protein as determined by NMR spectroscopy. The protein is made up of four antiparallel beta-strands, an alpha-helix, and a large unstructured stretch of residues at the N-terminus. It shows structural similarity to a family of DNA-binding proteins which interact with dsDNA via a three-stranded beta-sheet, suggesting that CedA may be a DNA-binding protein. The putative binding surface of CedA is predominantly positively charged with a number of basic residues surrounding a groove largely dominated by aromatic residues. NMR chemical shift perturbations and gel-shift experiments performed with CedA confirm that the protein binds dsDNA, and its interaction is mediated primarily via the beta-sheet.
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===SOLUTION STRUCTURE AND INTERACTIONS OF THE E.COLI CELL DIVISION ACTIVATOR PROTEIN CEDA===
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Solution structure and interactions of the Escherichia coli cell division activator protein CedA.,Chen HA, Simpson P, Huyton T, Roper D, Matthews S Biochemistry. 2005 May 10;44(18):6738-44. PMID:15865419<ref>PMID:15865419</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15865419}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bn8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15865419 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15865419}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BN8 OCA].
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==Reference==
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Solution structure and interactions of the Escherichia coli cell division activator protein CedA., Chen HA, Simpson P, Huyton T, Roper D, Matthews S, Biochemistry. 2005 May 10;44(18):6738-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15865419 15865419]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chen, H A.]]
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[[Category: Chen HA]]
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[[Category: Huyton, T.]]
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[[Category: Huyton T]]
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[[Category: Matthews, S.]]
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[[Category: Matthews S]]
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[[Category: Roper, D.]]
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[[Category: Roper D]]
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[[Category: Simpson, P.]]
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[[Category: Simpson P]]
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[[Category: Ceda]]
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[[Category: Cell cycle protein]]
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[[Category: Cell division activator protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:46:01 2008''
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Current revision

Solution Structure and interactions of the E .coli Cell Division Activator Protein CedA

PDB ID 2bn8

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